12-month randomised controlled trial of ginseng extract for moderate COPD.
Thorax
; 74(6): 539-545, 2019 06.
Article
em En
| MEDLINE
| ID: mdl-30940771
ABSTRACT
BACKGROUND:
Panax ginseng (ginseng) is a therapeutic herb which might be beneficial in COPD. The study investigated if ginseng, compared with placebo, is effective and safe for people with moderate COPD.METHODS:
This multicentre, randomised, double-blind, placebo-controlled trial compared 24 weeks of ginseng capsules (100 mg twice daily) with placebo. Participants were followed up for a further 24 weeks. Participants were aged 40 years and over and had airflow limitation in the moderate (Global Initiative for Chronic Obstructive Lung Disease 2) COPD range. The coprimary endpoints were the St George's Respiratory Questionnaire, the COPD Assessment Test and the Short Form Health Survey. Secondary outcomes included lung function, exacerbation rate and use of relief medication.FINDINGS:
168 participants were randomised 11 from five centres in Australia and China. Baseline characteristics were balanced between groups. There were no significant differences between ginseng and placebo, with overall results improving in both groups. Ginseng seemed safe for, and well tolerated by, people with COPD.INTERPRETATION:
There was no significant difference in improvement in health-related quality of life (primary outcome) between the ginseng and placebo groups. TRIAL REGISTRATION NUMBER ACTRN12610000768099.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Extratos Vegetais
/
Doença Pulmonar Obstrutiva Crônica
/
Panax
Tipo de estudo:
Clinical_trials
Limite:
Adult
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Aged
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Female
/
Humans
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Male
/
Middle aged
País/Região como assunto:
Asia
/
Oceania
Idioma:
En
Revista:
Thorax
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Austrália