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Evaluation of New 99mTc(CO)3 + Radiolabeled Glycylglycine In Vivo.
Senisik, Ahmet M; Içhedef, Çigdem; Kilçar, Ayfer Y; Uçar, Eser; Ari, Kadir; Parlak, Yasemin; Bilgin, Elvan S; Teksöz, Serap.
Afiliação
  • Senisik AM; Vocational School of Health Services/Radiotherapy, Altinbas University, 34144 Bakirköy, Istanbul, Turkey.
  • Içhedef Ç; Department of Nuclear Applications, Institue of Nuclear Sciences Ege University 35100 Bornova, Izmir, Turkey.
  • Kilçar AY; Department of Nuclear Applications, Institue of Nuclear Sciences Ege University 35100 Bornova, Izmir, Turkey.
  • Uçar E; Department of Nuclear Applications, Institue of Nuclear Sciences Ege University 35100 Bornova, Izmir, Turkey.
  • Ari K; Department of Nuclear Applications, Institue of Nuclear Sciences Ege University 35100 Bornova, Izmir, Turkey.
  • Parlak Y; Department of Nuclear Medicine, Celal Bayar University, 45030 Manisa, Turkey.
  • Bilgin ES; Department of Nuclear Medicine, Celal Bayar University, 45030 Manisa, Turkey.
  • Teksöz S; Department of Nuclear Applications, Institue of Nuclear Sciences Ege University 35100 Bornova, Izmir, Turkey.
Anticancer Agents Med Chem ; 19(11): 1382-1387, 2019.
Article em En | MEDLINE | ID: mdl-30947676
BACKGROUND: Peptide-based agents are used in molecular imaging due to their unique properties, such as rapid clearance from the circulation, high affinity and target selectivity. Many of the radiolabeled peptides have been clinically experienced with diagnostic accuracy. The aim of this study was to investigate in vivo biological behavior of [99mTc(CO)3(H2O)3]+ radiolabeled glycylglycine (GlyGly). METHODS: Glycylglycine was radiolabeled with a high radiolabeling yield of 94.69±2%, and quality control of the radiolabeling process was performed by thin layer radiochromatography (TLRC) and High-Performance Liquid Radiochromatography (HPLRC). Lipophilicity study for radiolabeled complex (99mTc(CO)3-Gly-Gly) was carried out using solvent extraction. The in vivo evaluation was performed by both biodistribution and SPECT imaging. RESULTS: The high radiolabelling yield of 99mTc(CO)3-GlyGly was obtained and verified by TLRC and HPLRC as well. According to the in vivo results, SPECT images and biodistribution data are in good accordance. The excretion route from the body was both hepatobiliary and renal. CONCLUSION: This study shows that 99mTc(CO)3-GlyGly has the potential to be used as a peptide-based imaging agent. Further studies, 99mTc(CO)3-GlyGly can be performed on tumor-bearing animals.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Monóxido de Carbono / Tecnécio / Compostos Radiofarmacêuticos / Glicilglicina Limite: Animals Idioma: En Revista: Anticancer Agents Med Chem Assunto da revista: ANTINEOPLASICOS / QUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Turquia

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Monóxido de Carbono / Tecnécio / Compostos Radiofarmacêuticos / Glicilglicina Limite: Animals Idioma: En Revista: Anticancer Agents Med Chem Assunto da revista: ANTINEOPLASICOS / QUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Turquia