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The Extracellular RNA Communication Consortium: Establishing Foundational Knowledge and Technologies for Extracellular RNA Research.
Das, Saumya; Ansel, K Mark; Bitzer, Markus; Breakefield, Xandra O; Charest, Alain; Galas, David J; Gerstein, Mark B; Gupta, Mihir; Milosavljevic, Aleksandar; McManus, Michael T; Patel, Tushar; Raffai, Robert L; Rozowsky, Joel; Roth, Matthew E; Saugstad, Julie A; Van Keuren-Jensen, Kendall; Weaver, Alissa M; Laurent, Louise C.
Afiliação
  • Das S; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Ansel KM; Department Microbiology & Immunology and Sandler Asthma Basic Research Center, University of California San Francisco, San Francisco, CA 94143, USA.
  • Bitzer M; Department of Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
  • Breakefield XO; Department of Neurology and Center for Molecular Imaging Research Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129 USA; Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA.
  • Charest A; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
  • Galas DJ; Pacific Northwest Research Institute, Seattle, WA 98122, USA.
  • Gerstein MB; Program in Computational Biology & Bioinformatics, Department of Molecular Biophysics & Biochemistry, Department of Computer Science, and Department of Statistics & Data Science, Yale University, New Haven, CT 06520, USA.
  • Gupta M; Department of Neurosurgery, University of California, San Diego, CA 92093, USA.
  • Milosavljevic A; Molecular and Human Genetics Department, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA; Program in Quantitative and Computational Biosciences, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.
  • McManus MT; Department of Microbiology and Immunology, University of California San Francisco Diabetes Center, WM Keck Center for Noncoding RNAs, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Patel T; Department of Transplantation, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Raffai RL; Department of Surgery, University of California San Francisco & Veterans Affairs Medical Center San Francisco, San Francisco, CA 94121, USA.
  • Rozowsky J; Department of Molecular Biophysics and Biochemistry, Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA.
  • Roth ME; Molecular and Human Genetics Department, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA; Program in Quantitative and Computational Biosciences, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.
  • Saugstad JA; Department of Anesthesiology & Perioperative Medicine, Oregon Health & Science University, Portland, OR 97239, USA.
  • Van Keuren-Jensen K; Neurogenomics, Translational Genomics Research Institute, Phoenix, AZ 85284, USA.
  • Weaver AM; Department of Cell and Developmental Biology, Vanderbilt University School of Medicine and Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  • Laurent LC; Department of Obstetrics, Gynecology, and Reproductive Sciences and Sanford Consortium for Regenerative Medicine, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: llaurent@ucsd.edu.
Cell ; 177(2): 231-242, 2019 04 04.
Article em En | MEDLINE | ID: mdl-30951667
The Extracellular RNA Communication Consortium (ERCC) was launched to accelerate progress in the new field of extracellular RNA (exRNA) biology and to establish whether exRNAs and their carriers, including extracellular vesicles (EVs), can mediate intercellular communication and be utilized for clinical applications. Phase 1 of the ERCC focused on exRNA/EV biogenesis and function, discovery of exRNA biomarkers, development of exRNA/EV-based therapeutics, and construction of a robust set of reference exRNA profiles for a variety of biofluids. Here, we present progress by ERCC investigators in these areas, and we discuss collaborative projects directed at development of robust methods for EV/exRNA isolation and analysis and tools for sharing and computational analysis of exRNA profiling data.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vesículas Extracelulares / Ácidos Nucleicos Livres Limite: Humans Idioma: En Revista: Cell Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vesículas Extracelulares / Ácidos Nucleicos Livres Limite: Humans Idioma: En Revista: Cell Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos