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Safety and clinical activity of the Notch inhibitor, crenigacestat (LY3039478), in an open-label phase I trial expansion cohort of advanced or metastatic adenoid cystic carcinoma.
Even, C; Lassen, U; Merchan, J; Le Tourneau, C; Soria, J-C; Ferte, C; Ricci, F; Diener, J T; Yuen, E; Smith, C; Oakley, G J; Benhadji, K A; Massard, Christophe.
Afiliação
  • Even C; Drug Development Department (DITEP), Institut Gustave Roussy Cancer Campus, 114 rue Edouard Vaillant, 94800, Villejuif Cedex, France.
  • Lassen U; The Finsen Centre, Rigshospitalet, Copenhagen, Denmark.
  • Merchan J; University of Miami Miller School of Medicine, Miami, FL, USA.
  • Le Tourneau C; Department of Drug Development and Innovation (D3i), Institut Curie, Paris, France.
  • Soria JC; INSERM U900 Research Unit, Saint-Cloud, France.
  • Ferte C; Paris-Saclay University, Paris, France.
  • Ricci F; Drug Development Department (DITEP), Institut Gustave Roussy Cancer Campus, 114 rue Edouard Vaillant, 94800, Villejuif Cedex, France.
  • Diener JT; University Paris-Sud, Orsay, France.
  • Yuen E; Drug Development Department (DITEP), Institut Gustave Roussy Cancer Campus, 114 rue Edouard Vaillant, 94800, Villejuif Cedex, France.
  • Smith C; Department of Drug Development and Innovation (D3i), Institut Curie, Paris, France.
  • Oakley GJ; Eli Lilly and Company, Indianapolis, IN, USA.
  • Benhadji KA; Eli Lilly and Company, Indianapolis, IN, USA.
  • Massard C; Eli Lilly and Company, Indianapolis, IN, USA.
Invest New Drugs ; 38(2): 402-409, 2020 04.
Article em En | MEDLINE | ID: mdl-30953269
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benzazepinas / Carcinoma Adenoide Cístico / Receptor Notch1 / Antineoplásicos Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Invest New Drugs Ano de publicação: 2020 Tipo de documento: Article País de afiliação: França
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benzazepinas / Carcinoma Adenoide Cístico / Receptor Notch1 / Antineoplásicos Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Invest New Drugs Ano de publicação: 2020 Tipo de documento: Article País de afiliação: França