Upregulation of CBP by PLY can cause permeability of blood-brain barrier to increase meningitis.
J Biochem Mol Toxicol
; 33(7): e22333, 2019 Jul.
Article
em En
| MEDLINE
| ID: mdl-30980515
ABSTRACT
BACKGROUND:
Streptococcus pneumoniae causes many human diseases including bacterial meningitis. Previous study proposed that pneumolysin (PLY), a cytotoxin from pneumococcus, is related to the infection across blood-brain barrier (BBB). However, the mechanism of how PLY break through BBB remains elusive. The present study showed that PLY can increase the permeability of BBB both in vitro and in vivo in our experiments.RESULTS:
Further we found out that PLY leads to the high expression of CERB-binding protein (CBP) which can lead to releasing of tumor necrosis factor α then enhance apoptosis of cells which is a significant factor leading to permeabilization of BBB.CONCLUSION:
Our findings demonstrate that CBP plays an important role in the pneumococcus infection in the brain and could be a potential therapeutic target against pneumococcal meningitis.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosfoproteínas
/
Streptococcus pneumoniae
/
Estreptolisinas
/
Barreira Hematoencefálica
/
Regulação para Cima
/
Proteínas de Membrana
/
Meningite Pneumocócica
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
J Biochem Mol Toxicol
Assunto da revista:
BIOLOGIA MOLECULAR
/
BIOQUIMICA
/
TOXICOLOGIA
Ano de publicação:
2019
Tipo de documento:
Article