Delta-secretase-cleaved Tau antagonizes TrkB neurotrophic signalings, mediating Alzheimer's disease pathologies.

Xiang, Jie; Wang, Zhi-Hao; Ahn, Eun Hee; Liu, Xia; Yu, Shan-Ping; Manfredsson, Fredric P; Sandoval, Ivette M; Ju, Gong; Wu, Shengxi; Ye, Keqiang

Xiang, Jie; Wang, Zhi-Hao; Ahn, Eun Hee; Liu, Xia; Yu, Shan-Ping; Manfredsson, Fredric P; Sandoval, Ivette M; Ju, Gong; Wu, Shengxi; Ye, Keqiang.

Afiliação

Xiang J; Department of Neurobiology, Fourth Military Medical University, Xi'an, 710032 Shaanxi, People's Republic of China.
Wang ZH; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322.
Ahn EH; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322.
Liu X; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322.
Yu SP; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322.
Manfredsson FP; Department of Anesthesiology, Emory University School of Medicine, Atlanta, GA 30322.
Sandoval IM; Department of Translational Science & Molecular Medicine, Michigan State University, Grand Rapids, MI 49503.
Ju G; Department of Translational Science & Molecular Medicine, Michigan State University, Grand Rapids, MI 49503.
Wu S; Department of Neurobiology, Fourth Military Medical University, Xi'an, 710032 Shaanxi, People's Republic of China.
Ye K; Department of Neurobiology, Fourth Military Medical University, Xi'an, 710032 Shaanxi, People's Republic of China.

Proc Natl Acad Sci U S A ; 116(18): 9094-9102, 2019 04 30.

Article em En | MEDLINE | ID: mdl-31004063

Assuntos

Secretases da Proteína Precursora do Amiloide/metabolismo; Receptor trkB/antagonistas & inibidores; Proteínas tau/metabolismo; Doença de Alzheimer/metabolismo; Doença de Alzheimer/fisiopatologia; Peptídeos beta-Amiloides/metabolismo; Animais; Encéfalo/metabolismo; Fator Neurotrófico Derivado do Encéfalo/metabolismo; Linhagem Celular; Cognição/fisiologia; Disfunção Cognitiva/metabolismo; Cisteína Endopeptidases/metabolismo; Feminino; Humanos; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Emaranhados Neurofibrilares/metabolismo; Neurônios/metabolismo; Fosforilação; Cultura Primária de Células; Proteínas Proto-Oncogênicas c-akt/metabolismo; Receptor trkB/metabolismo; Transdução de Sinais

Palavras-chave

AEP; Alzheimer's disease; BDNF deprivation; Tau N368; Tauopathy

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas tau / Receptor trkB / Secretases da Proteína Precursora do Amiloide Limite: Animals / Female / Humans / Male Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2019 Tipo de documento: Article

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