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Highly Stretchable and Strain-Insensitive Fiber-Based Wearable Electrochemical Biosensor to Monitor Glucose in the Sweat.
Zhao, Yunmeng; Zhai, Qingfeng; Dong, Dashen; An, Tiance; Gong, Shu; Shi, Qianqian; Cheng, Wenlong.
Afiliação
  • Zhao Y; Department of Chemical Engineering , Monash University , Clayton , Victoria 3800 , Australia.
  • Zhai Q; The Melbourne Centre for Nanofabrication , Clayton , Victoria 3800 , Australia.
  • Dong D; Department of Chemical Engineering , Monash University , Clayton , Victoria 3800 , Australia.
  • An T; The Melbourne Centre for Nanofabrication , Clayton , Victoria 3800 , Australia.
  • Gong S; Department of Chemical Engineering , Monash University , Clayton , Victoria 3800 , Australia.
  • Shi Q; The Melbourne Centre for Nanofabrication , Clayton , Victoria 3800 , Australia.
  • Cheng W; Department of Chemical Engineering , Monash University , Clayton , Victoria 3800 , Australia.
Anal Chem ; 91(10): 6569-6576, 2019 05 21.
Article em En | MEDLINE | ID: mdl-31006229
Development of high-performance fiber-shaped wearable sensors is of great significance for next-generation smart textiles for real-time and out-of-clinic health monitoring. The previous focus has been mainly on monitoring physical parameters such as pressure and strains associated with human activities. Development of an enzyme-based non-invasive wearable electrochemical sensor to monitor biochemical vital signs of health such as the glucose level in sweat has attracted increasing attention recently, due to the unmet clinical needs for the diabetic patients. To achieve this, the key challenge lies in the design of a highly stretchable fiber with high conductivity, facile enzyme immobilization, and strain-insensitive properties. Herein, we demonstrate an elastic gold fiber-based three-electrode electrochemical platform that can meet the aforementioned criteria toward wearable textile glucose biosensing. The gold fiber could be functionalized with Prussian blue and glucose oxidase to obtain the working electrode and modified by Ag/AgCl to serve as the reference electrode; and the nonmodified gold fiber could serve as the counter electrode. The as-fabricated textile glucose biosensors achieved a linear range of 0-500 µM and a sensitivity of 11.7 µA mM-1 cm-2. Importantly, such sensing performance could be maintained even under a large strain of 200%, indicating the potential applications in real-world wearable biochemical diagnostics from human sweat.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Técnicas Eletroquímicas / Dispositivos Eletrônicos Vestíveis / Glucose Limite: Humans Idioma: En Revista: Anal Chem Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Austrália

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Técnicas Eletroquímicas / Dispositivos Eletrônicos Vestíveis / Glucose Limite: Humans Idioma: En Revista: Anal Chem Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Austrália