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Assessing Drug-Induced Long QT and Proarrhythmic Risk Using Human Stem-Cell-Derived Cardiomyocytes in a Ca2+ Imaging Assay: Evaluation of 28 CiPA Compounds at Three Test Sites.
Lu, Hua Rong; Zeng, Haoyu; Kettenhofen, Ralf; Guo, Liang; Kopljar, Ivan; van Ammel, Karel; Tekle, Fetene; Teisman, Ard; Zhai, Jin; Clouse, Holly; Pierson, Jennifer; Furniss, Michael; Lagrutta, Armando; Sannajust, Frederick; Gallacher, David J.
Afiliação
  • Lu HR; Janssen Pharmaceutica NV (J&J), 2340 Beerse, Belgium.
  • Zeng H; Safety and Exploratory Pharmacology, Merck Sharp & Dohme Corp. (MSD), West Point, Pennsylvania.
  • Kettenhofen R; Ncardia AG, 50829 Cologne, Germany.
  • Guo L; Frederick National Laboratory for Cancer Research (FNLCR)/Leidos Biomedical Research (LBR), Inc., Frederick, Maryland 21702.
  • Kopljar I; Janssen Pharmaceutica NV (J&J), 2340 Beerse, Belgium.
  • van Ammel K; Janssen Pharmaceutica NV (J&J), 2340 Beerse, Belgium.
  • Tekle F; Janssen Pharmaceutica NV (J&J), 2340 Beerse, Belgium.
  • Teisman A; Janssen Pharmaceutica NV (J&J), 2340 Beerse, Belgium.
  • Zhai J; Safety and Exploratory Pharmacology, Merck Sharp & Dohme Corp. (MSD), West Point, Pennsylvania.
  • Clouse H; Safety and Exploratory Pharmacology, Merck Sharp & Dohme Corp. (MSD), West Point, Pennsylvania.
  • Pierson J; HESI, Cardiac Safety Technical Committee, Washington, District of Columbia 20005.
  • Furniss M; Frederick National Laboratory for Cancer Research (FNLCR)/Leidos Biomedical Research (LBR), Inc., Frederick, Maryland 21702.
  • Lagrutta A; Safety and Exploratory Pharmacology, Merck Sharp & Dohme Corp. (MSD), West Point, Pennsylvania.
  • Sannajust F; Safety and Exploratory Pharmacology, Merck Sharp & Dohme Corp. (MSD), West Point, Pennsylvania.
  • Gallacher DJ; Janssen Pharmaceutica NV (J&J), 2340 Beerse, Belgium.
Toxicol Sci ; 170(2): 345-356, 2019 08 01.
Article em En | MEDLINE | ID: mdl-31020317
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Arritmias Cardíacas / Síndrome do QT Longo / Cálcio / Miócitos Cardíacos Tipo de estudo: Etiology_studies / Evaluation_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Toxicol Sci Assunto da revista: TOXICOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Bélgica
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Arritmias Cardíacas / Síndrome do QT Longo / Cálcio / Miócitos Cardíacos Tipo de estudo: Etiology_studies / Evaluation_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Toxicol Sci Assunto da revista: TOXICOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Bélgica