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Stochasticity of Biological Soft Matter: Emerging Concepts in Intrinsically Disordered Proteins and Biological Phase Separation.
Turoverov, Konstantin K; Kuznetsova, Irina M; Fonin, Alexander V; Darling, April L; Zaslavsky, Boris Y; Uversky, Vladimir N.
Afiliação
  • Turoverov KK; Laboratory of Structural Dynamics, Stability and Folding of Proteins, Institute of Cytology, Russian Academy of Sciences, St. Petersburg 194064, Russia; Peter the Great St. Petersburg Polytechnic University, Department of Biophysics, Polytechnicheskaya Av. 29, St. Petersburg 195251, Russia. Electron
  • Kuznetsova IM; Laboratory of Structural Dynamics, Stability and Folding of Proteins, Institute of Cytology, Russian Academy of Sciences, St. Petersburg 194064, Russia.
  • Fonin AV; Laboratory of Structural Dynamics, Stability and Folding of Proteins, Institute of Cytology, Russian Academy of Sciences, St. Petersburg 194064, Russia.
  • Darling AL; Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
  • Zaslavsky BY; Analiza, Inc., 3615 Superior Avenue, Cleveland, OH 44114, USA.
  • Uversky VN; Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA. Electronic address: vuversky@health.usf.edu.
Trends Biochem Sci ; 44(8): 716-728, 2019 08.
Article em En | MEDLINE | ID: mdl-31023505
ABSTRACT
At the turn of this century, cardinal changes took place in the perceptions of the structure and function of proteins, as well as in the organizational principles of membrane-less organelles. As a result, the model of the organization of living matter is changing to one described by highly dynamic biological soft matter positioned at the edge of chaos. Intrinsically disordered proteins (IDPs) and membrane-less organelles are key examples of this new outlook and may represent a critical foundation of life, defining its complexity and the evolution of living things.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Materiais Biocompatíveis / Proteínas Intrinsicamente Desordenadas Idioma: En Revista: Trends Biochem Sci Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Materiais Biocompatíveis / Proteínas Intrinsicamente Desordenadas Idioma: En Revista: Trends Biochem Sci Ano de publicação: 2019 Tipo de documento: Article