Hydrogen sulfide, a novel small molecule signalling agent, participates in the regulation of ganoderic acids biosynthesis induced by heat stress in Ganoderma lucidum.
Fungal Genet Biol
; 130: 19-30, 2019 09.
Article
em En
| MEDLINE
| ID: mdl-31028914
ABSTRACT
Hydrogen sulfide (H2S), an emerging small-molecule signalling agent, was recently shown to play a significant role in many physiological processes, but relatively few studies have been conducted on microorganisms compared with mammals and plants. By studying the pretreatment of H2S donor sodium hydrosulfide (NaHS) and the scavenger hypotaurine (HT) and Cystathionine ß-synthase silenced strains, we found that H2S could alleviate the HS-induced ganoderic acids (GAs) biosynthesis. Our transcriptome results also showed that many signaling pathways and metabolic pathways, such as the glycolysis, TCA, oxidative phosphorylation and pentose phosphate pathway, are influenced by H2S. Further experimental results indicated that H2S could affect the physiological process of Ganoderma lucidum by interacting with multiple signals, including ROS, NO, AMPK, sphingolipid, mTOR, phospholipase D and MAPK, and physiological and pharmacological analyses showed that H2S might alleviate the biosynthesis of GAs by inhibiting the intracellular calcium in G. lucidum.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Triterpenos
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Transdução de Sinais
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Resposta ao Choque Térmico
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Reishi
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Sulfeto de Hidrogênio
Idioma:
En
Revista:
Fungal Genet Biol
Assunto da revista:
GENETICA
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MICROBIOLOGIA
Ano de publicação:
2019
Tipo de documento:
Article