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Correlation of body mass index (BMI), anti-mullerian hormone (AMH), and insulin resistance among different polycystic ovary syndrome (PCOS) phenotypes - a cross-sectional study.
Gupta, Monica; Yadav, Ritu; Mahey, Reeta; Agrawal, Anisha; Upadhyay, Ashish; Malhotra, Neena; Bhatla, Neerja.
Afiliação
  • Gupta M; Department of Obstetrics and Gynecology, All India Institute of Medical Sciences , New Delhi , India.
  • Yadav R; Department of Obstetrics and Gynecology, All India Institute of Medical Sciences , New Delhi , India.
  • Mahey R; Department of Obstetrics and Gynecology, All India Institute of Medical Sciences , New Delhi , India.
  • Agrawal A; Department of Obstetrics and Gynecology, All India Institute of Medical Sciences , New Delhi , India.
  • Upadhyay A; Department of Biostatistics, All India Institute of Medical Sciences , New Delhi , India.
  • Malhotra N; Department of Obstetrics and Gynecology, All India Institute of Medical Sciences , New Delhi , India.
  • Bhatla N; Department of Obstetrics and Gynecology, All India Institute of Medical Sciences , New Delhi , India.
Gynecol Endocrinol ; 35(11): 970-973, 2019 Nov.
Article em En | MEDLINE | ID: mdl-31081410
ABSTRACT
One hundred and fifty infertile polycystic ovary syndrome (PCOS) women were classified into four phenotypes on the basis of Rotterdam criteria. Homeostatic model assessment of insulin resistance (HOMA-IR) with a cutoff ≥2.5 was considered as a measure of insulin resistance (IR). Maximum number of patients, 57 (38%) in our cohort belonged to phenotype A or the classical phenotype with all 3 features of Rotterdam criteria. Mean body mass index (BMI) in all phenotypes was more than 25 kg/m2 and the highest was seen in phenotype B. According to BMI categories in the four phenotypes, more number of women was in the obese category in phenotype A (24.5%) and B (56.5%) in comparison to phenotype C (18.2%) and D (10.8%) (p<.001). There was no difference in median HOMA-IR among different phenotype categories (p=.718). The median value of anti-mullerian hormone (AMH) was highest in phenotype A (11.68 ng/ml [7.94-16.46]) and significantly more in comparison to B phenotype (Kruskal-Wallis, p=.018). Thus there is heterogeneity in AMH levels and BMI in different PCOS phenotypes with higher levels in the most severe phenotypes. There is, however, no correlation of IR among the different phenotype groups and further investigation is needed to characterize its role in phenotypic classification.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome do Ovário Policístico / Resistência à Insulina / Índice de Massa Corporal / Hormônio Antimülleriano Tipo de estudo: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans País/Região como assunto: Asia Idioma: En Revista: Gynecol Endocrinol Assunto da revista: ENDOCRINOLOGIA / GINECOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Índia

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome do Ovário Policístico / Resistência à Insulina / Índice de Massa Corporal / Hormônio Antimülleriano Tipo de estudo: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans País/Região como assunto: Asia Idioma: En Revista: Gynecol Endocrinol Assunto da revista: ENDOCRINOLOGIA / GINECOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Índia