GPER1 influences cellular homeostasis and cytostatic drug resistance via influencing long chain ceramide synthesis in breast cancer cells.

Wegner, Marthe-Susanna; Gruber, Lisa; Schömel, Nina; Trautmann, Sandra; Brachtendorf, Sebastian; Fuhrmann, Dominik; Schreiber, Yannick; Olesch, Catherine; Brüne, Bernhard; Geisslinger, Gerd; Grösch, Sabine

Wegner, Marthe-Susanna; Gruber, Lisa; Schömel, Nina; Trautmann, Sandra; Brachtendorf, Sebastian; Fuhrmann, Dominik; Schreiber, Yannick; Olesch, Catherine; Brüne, Bernhard; Geisslinger, Gerd; Grösch, Sabine.

Afiliação

Wegner MS; pharmazentrum frankfurt/ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Theodor Stern-Kai 7, 60590 Frankfurt am Main, Germany. Electronic address: wegner@med.uni-frankfurt.de.
Gruber L; pharmazentrum frankfurt/ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Theodor Stern-Kai 7, 60590 Frankfurt am Main, Germany.
Schömel N; pharmazentrum frankfurt/ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Theodor Stern-Kai 7, 60590 Frankfurt am Main, Germany.
Trautmann S; pharmazentrum frankfurt/ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Theodor Stern-Kai 7, 60590 Frankfurt am Main, Germany.
Brachtendorf S; pharmazentrum frankfurt/ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Theodor Stern-Kai 7, 60590 Frankfurt am Main, Germany.
Fuhrmann D; Faculty of Medicine, Institute of Biochemistry I, Johann Wolfgang Goethe University, Theodor Stern-Kai 7, 60590 Frankfurt am Main, Germany.
Schreiber Y; Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine and Pharmacology (TMP), Theodor Stern-Kai 7, 60590 Frankfurt am Main, Germany.
Olesch C; Faculty of Medicine, Institute of Biochemistry I, Johann Wolfgang Goethe University, Theodor Stern-Kai 7, 60590 Frankfurt am Main, Germany.
Brüne B; Faculty of Medicine, Institute of Biochemistry I, Johann Wolfgang Goethe University, Theodor Stern-Kai 7, 60590 Frankfurt am Main, Germany.
Geisslinger G; pharmazentrum frankfurt/ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Theodor Stern-Kai 7, 60590 Frankfurt am Main, Germany; Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Project Group Translational Medicine and Pharmacology (TMP), Theodor Stern-
Grösch S; pharmazentrum frankfurt/ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Theodor Stern-Kai 7, 60590 Frankfurt am Main, Germany.

Int J Biochem Cell Biol ; 112: 95-106, 2019 07.

Article em En | MEDLINE | ID: mdl-31082617

Assuntos

Neoplasias da Mama/metabolismo; Ceramidas/biossíntese; Citostáticos/farmacologia; Resistencia a Medicamentos Antineoplásicos/efeitos dos fármacos; Homeostase/efeitos dos fármacos; Proteínas de Neoplasias/metabolismo; Oxirredutases/metabolismo; Receptores de Estrogênio/metabolismo; Receptores Acoplados a Proteínas G/metabolismo; Neoplasias da Mama/genética; Neoplasias da Mama/patologia; Ceramidas/genética; Feminino; Pontos de Checagem da Fase G1 do Ciclo Celular; Humanos; Células MCF-7; Proteínas de Neoplasias/genética; Oxirredutases/genética; Receptores de Estrogênio/genética; Receptores Acoplados a Proteínas G/genética

Palavras-chave

Autophagy; Cell cycle progression; Glycolysis; Mitochondrial stress; Sphingolipids

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oxirredutases / Neoplasias da Mama / Receptores de Estrogênio / Ceramidas / Resistencia a Medicamentos Antineoplásicos / Receptores Acoplados a Proteínas G / Citostáticos / Homeostase / Proteínas de Neoplasias Limite: Female / Humans Idioma: En Revista: Int J Biochem Cell Biol Assunto da revista: BIOQUIMICA Ano de publicação: 2019 Tipo de documento: Article

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