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Fasudil dichloroacetate (FDCA), an orally available agent with potent therapeutic efficiency on monocrotaline-induced pulmonary arterial hypertension rats.
Qi, Lei; Lv, Tian; Cheng, Yusheng; Yu, Min; Han, Honghao; Kong, Hui; Xie, Weiping; Wang, Hong; Zhang, Yihua; Huang, Zhangjian.
Afiliação
  • Qi L; Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu 210029, PR China; The Affiliated Hospital of Nantong University, 20 West Temple Road, Nantong, Jiangsu 226001, PR China.
  • Lv T; State Key Laboratory of Natural Medicines, Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, PR China.
  • Cheng Y; Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu 210029, PR China.
  • Yu M; Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu 210029, PR China.
  • Han H; Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu 210029, PR China.
  • Kong H; Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu 210029, PR China.
  • Xie W; Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu 210029, PR China.
  • Wang H; Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu 210029, PR China. Electronic address: hongwang@njmu.edu.cn.
  • Zhang Y; State Key Laboratory of Natural Medicines, Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, PR China. Electronic address: zyhtgd@163.com.
  • Huang Z; State Key Laboratory of Natural Medicines, Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, PR China. Electronic address: zhangjianhuang@cpu.edu.cn.
Bioorg Med Chem Lett ; 29(14): 1812-1818, 2019 07 15.
Article em En | MEDLINE | ID: mdl-31088713
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: 1-(5-Isoquinolinasulfonil)-2-Metilpiperazina / Inibidores de Proteínas Quinases / Hipertensão Arterial Pulmonar Limite: Animals Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2019 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: 1-(5-Isoquinolinasulfonil)-2-Metilpiperazina / Inibidores de Proteínas Quinases / Hipertensão Arterial Pulmonar Limite: Animals Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2019 Tipo de documento: Article