Tissue-dependent variation of hydrogen sulfide homeostasis in anoxic freshwater turtles.
J Exp Biol
; 222(Pt 12)2019 06 19.
Article
em En
| MEDLINE
| ID: mdl-31109970
ABSTRACT
Hydrogen sulfide (H2S) controls numerous physiological responses. To understand its proposed role in metabolic suppression, we measured free H2S and bound sulfane sulfur (BSS) in tissues of the freshwater turtle Trachemys scriptaelegans, a species undergoing strong metabolic suppression when cold and anoxic. In warm normoxic turtles, free H2S was higher in red blood cells (RBCs) and kidney (â¼9-10â
µmol l-1) than in brain, liver and lung (â¼1-2â
µmol l-1). These values overall aligned with the tissue H2S-generating enzymatic activity. BSS levels were similar in all tissues (â¼0.5â
µmol l-1) but â¼100-fold higher in RBCs, which have a high thiol content, suggesting that RBCs function as a circulating H2S reservoir. Cold acclimation caused significant changes in free and bound H2S in liver, brain and RBCs, but anoxia had no further effect, except in the brain. These results show tissue-dependent sulfide signaling with a potential role in brain metabolic suppression during anoxia in turtles.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tartarugas
/
Homeostase
/
Sulfeto de Hidrogênio
Limite:
Animals
Idioma:
En
Revista:
J Exp Biol
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Dinamarca