Urinary angiotensinogen in pediatric urinary tract infection.
Pediatr Int
; 61(7): 712-714, 2019 Jul.
Article
em En
| MEDLINE
| ID: mdl-31120634
ABSTRACT
BACKGROUND:
Urinary tract infection (UTI) is one of the most common diseases in children, and urinary angiotensinogen (U-AGT) is a new biomarker gathering attention in many renal diseases. U-AGT reflects intrarenal renin-angiotensin system (RAS) activity. We conducted a study to measure U-AGT in children <4 months old with UTI.METHODS:
All children <4 months old who came to Toshima Hospital with fever between January 2015 and December 2015 were included. Patients were divided into a UTI group and a non-UTI group, and U-AGT was measured.RESULTS:
Median U-AGT was higher in patients with UTI compared with patients without UTI (0.56 ng/dL, range, 0.025-2.753 ng/dL vs 0.13 ng/dL, range, 0.008-1.697 ng/dL, respectively; P < 0.05).CONCLUSIONS:
U-AGT is elevated in UTI patients, and RAS activation may contribute to renal injury caused by UTI.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções Urinárias
/
Angiotensinogênio
Tipo de estudo:
Observational_studies
Limite:
Female
/
Humans
/
Infant
/
Male
/
Newborn
Idioma:
En
Revista:
Pediatr Int
Assunto da revista:
PEDIATRIA
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Japão