Decreased let-7b is associated with poor prognosis in glioma.
Medicine (Baltimore)
; 98(22): e15784, 2019 May.
Article
em En
| MEDLINE
| ID: mdl-31145301
ABSTRACT
Abnormal expression of let-7b has been observed in many tumors, including glioma. However, the clinical significance of let-7b in glioma remained unclear. The aim of the study was to explore the correlation of let-7b expression with clinicopathological factors and prognosis in human glioma.Quantitative real-time polymerase chain reaction (qRT-PCR) was carried out to detect the relative expression of let-7b in glioma tissues. The association of let-7b expression with clinicopatholoigcal features of glioma patients was estimated using chi-square test. Overall survival curves were plotted using Kaplan-Meier method with log rank test. The prognosis analysis was performed using Cox regression model, and the results were shown as hazard ration (HR) with 95% confidence interval (CI).The relative expression of let-7b was significantly lower in glioma tissues than that in normal brain tissues (Pâ<â.001). Furthermore, let-7b level was closely correlated with World Health Organization (WHO) grade (Pâ=â.027) and Karnofsky performance score (KPS) (Pâ=â.018). Survival analysis indicated that glioma patients with low let-7b expression had significantly shorter overall survival time than those with high expression (log rank test, Pâ<â.001). Let-7b might be an independent prognostic biomarker for glioma (Pâ<â.001, HRâ=â2.415; 95% CI 1.531-3.808).Let-7b may be a promising prognostic factor in glioma.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Encefálicas
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MicroRNAs
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Glioma
Tipo de estudo:
Evaluation_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Medicine (Baltimore)
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
China