Insights into IgM-mediated complement activation based on in situ structures of IgM-C1-C4b.

Sharp, Thomas H; Boyle, Aimee L; Diebolder, Christoph A; Kros, Alexander; Koster, Abraham J; Gros, Piet

Sharp, Thomas H; Boyle, Aimee L; Diebolder, Christoph A; Kros, Alexander; Koster, Abraham J; Gros, Piet.

Afiliação

Sharp TH; Department of Cell and Chemical Biology, Section Electron Microscopy, Leiden University Medical Center, 2300 RC Leiden, The Netherlands; t.sharp@lumc.nl.
Boyle AL; Leiden Institute of Chemistry, Gorlaeus Laboratories, Leiden University, 2333 CC Leiden, The Netherlands.
Diebolder CA; The Netherlands Centre for Electron Nanoscopy (NeCEN), Gorlaeus Laboratories, Leiden University, 2333 CC Leiden, The Netherlands.
Kros A; Leiden Institute of Chemistry, Gorlaeus Laboratories, Leiden University, 2333 CC Leiden, The Netherlands.
Koster AJ; Department of Cell and Chemical Biology, Section Electron Microscopy, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
Gros P; Crystal and Structural Chemistry, Bijvoet Center for Biomolecular Research, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands.

Proc Natl Acad Sci U S A ; 116(24): 11900-11905, 2019 06 11.

Article em En | MEDLINE | ID: mdl-31147461

Assuntos

Ativação do Complemento/imunologia; Complemento C1/imunologia; Complemento C4/imunologia; Imunoglobulina M/imunologia; Anticorpos/imunologia; Antígenos/imunologia; Sítios de Ligação/imunologia; Humanos; Modelos Moleculares

Palavras-chave

C1; IgM; complement; cryoelectron tomography; subtomogram averaging

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complemento C1 / Complemento C4 / Imunoglobulina M / Ativação do Complemento Limite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2019 Tipo de documento: Article

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