Exercise-induced cardiac opioid system activation attenuates apoptosis pathway in obese rats.
Life Sci
; 231: 116542, 2019 Aug 15.
Article
em En
| MEDLINE
| ID: mdl-31176781
ABSTRACT
AIM:
To compare the effect of 150â¯min vs. 300â¯min of weekly moderate intensity exercise training on the activation of the opioid system and apoptosis in the hearts of a diet-induced obesity model.METHODS:
Male Wistar rats were fed with either control (CON) or high fat (HF) diet for 32â¯weeks. At the 20th week, HF group was subdivided into sedentary, low (LEV, 150â¯min·week-1) or high (HEV, 300â¯min·week-1) exercise volume. After 12â¯weeks of exercise, body mass gain, adiposity index, systolic blood pressure, cardiac morphometry, apoptosis biomarkers and opioid system expression were evaluated.RESULTS:
Sedentary animals fed with HF presented pathological cardiac hypertrophy and higher body mass gain, systolic blood pressure and adiposity index than control group. Both exercise volumes induced physiological cardiac hypertrophy, restored systolic blood pressure and improved adiposity index, but only 300â¯min·week-1 reduced body mass gain. HF group exhibited lower proenkephalin, PI3K, ERK and GSK-3ß expression, and greater activated caspase-3 expression than control group. Compared to HF, no changes in the cardiac opioid system were observed in the 150â¯min·week-1 of exercise training, while 300â¯min·week-1 showed greater proenkephalin, DOR, KOR, MOR, Akt, ERK and GSK-3ß expression, and lower activated caspase-3 expression.CONCLUSION:
300â¯min·week-1 of exercise training triggered opioid system activation and provided greater cardioprotection against obesity than 150â¯min·week-1. Our findings provide translational aspect with clinical relevance about the critical dose of exercise training necessary to reduce cardiovascular risk factors caused by obesity.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Condicionamento Físico Animal
/
Cardiomegalia
/
Receptores Opioides
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Animals
Idioma:
En
Revista:
Life Sci
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Brasil