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Phenanthrene, but not its isomer anthracene, effectively activates both human and mouse nuclear receptor constitutive androstane receptor (CAR) and induces hepatotoxicity in mice.
Yang, Han; Shi, Zhe; Wang, Xiao-Xiao; Cheng, Rong; Lu, Min; Zhu, Jiayin; Deng, Wenhai; Zeng, Yuyao; Zhao, Li-Yang; Zhang, Shu-Yun.
Afiliação
  • Yang H; Department of Preventive Medicine, School of Public Health and Management, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
  • Shi Z; Department of Preventive Medicine, School of Public Health and Management, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
  • Wang XX; Department of Preventive Medicine, School of Public Health and Management, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
  • Cheng R; Department of Preventive Medicine, School of Public Health and Management, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
  • Lu M; Department of Anorectal Surgery, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
  • Zhu J; Laboratory of Animal Center, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
  • Deng W; Zhejiang Provincial Key Laboratory for Technology and Application of Model Organisms, Key Laboratory of Laboratory Medicine, Ministry of Education of China, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
  • Zeng Y; Wenzhou Institute of Industry and Science, Wenzhou, Zhejiang 325035, China.
  • Zhao LY; Department of Preventive Medicine, School of Public Health and Management, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
  • Zhang SY; Department of Preventive Medicine, School of Public Health and Management, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China. Electronic address: shuyunzh@yahoo.com.
Toxicol Appl Pharmacol ; 378: 114618, 2019 09 01.
Article em En | MEDLINE | ID: mdl-31181217
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenantrenos / Doença Hepática Induzida por Substâncias e Drogas / Fígado / Antracenos Limite: Animals / Humans / Male Idioma: En Revista: Toxicol Appl Pharmacol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenantrenos / Doença Hepática Induzida por Substâncias e Drogas / Fígado / Antracenos Limite: Animals / Humans / Male Idioma: En Revista: Toxicol Appl Pharmacol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China