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Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns.
Czamara, Darina; Eraslan, Gökçen; Page, Christian M; Lahti, Jari; Lahti-Pulkkinen, Marius; Hämäläinen, Esa; Kajantie, Eero; Laivuori, Hannele; Villa, Pia M; Reynolds, Rebecca M; Nystad, Wenche; Håberg, Siri E; London, Stephanie J; O'Donnell, Kieran J; Garg, Elika; Meaney, Michael J; Entringer, Sonja; Wadhwa, Pathik D; Buss, Claudia; Jones, Meaghan J; Lin, David T S; MacIsaac, Julie L; Kobor, Michael S; Koen, Nastassja; Zar, Heather J; Koenen, Karestan C; Dalvie, Shareefa; Stein, Dan J; Kondofersky, Ivan; Müller, Nikola S; Theis, Fabian J; Räikkönen, Katri; Binder, Elisabeth B.
Afiliação
  • Czamara D; Max-Planck-Institute of Psychiatry, Department of Translational Research in Psychiatry, Munich, 80804, Germany.
  • Eraslan G; Institute of Computational Biology, Helmholtz-Zentrum München, German Research Center for Environmental Health, Neuherberg, 85764, Germany.
  • Page CM; School of Life Sciences, Weihenstephan, Technische Universität München, Freising, 85354, Germany.
  • Lahti J; Oslo Centre for Biostatistics and Epidemiology, Research Support Unit, Oslo University Hospital, Oslo, 0372, Norway.
  • Lahti-Pulkkinen M; Center for Fertility and Health, Norwegian Institute of Public Health, Oslo, 0213, Norway.
  • Hämäläinen E; Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, 00014, Finland.
  • Kajantie E; Helsinki Collegium for Advanced Studies, University of Helsinki, Helsinki, 00101, Finland.
  • Laivuori H; Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, 00014, Finland.
  • Villa PM; British Heart Foundation Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, EH16 4TJ, UK.
  • Reynolds RM; HUSLAB and Department of Clinical Chemistry, Helsinki University, Helsinki, 00290, Finland.
  • Nystad W; Oulu University Hospital and University of Oulu, PEDEGO Research Unit, MRC Oulu, 90014, Finland.
  • Håberg SE; Hospital for Children and Adolescents, University of Helsinki and Helsinki University Hospital, Helsinki, 00029, Finland.
  • London SJ; National Institute for Health and Welfare, Helsinki, 00271, Finland.
  • O'Donnell KJ; Medical and Clinical Genetics and Obstetrics and Gynaecology University of Helsinki and Helsinki University Central Hospital, Helsinki, 00014, Finland.
  • Garg E; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, 00014, Finland.
  • Meaney MJ; Faculty of Medicine and Life Sciences, University of Tampere, Tampere, 33100, Finland.
  • Entringer S; Department of Obstetrics and Gynecology, Tampere University Hospital, Tampere, 33100, Finland.
  • Wadhwa PD; Medical and Clinical Genetics and Obstetrics and Gynaecology University of Helsinki and Helsinki University Central Hospital, Helsinki, 00014, Finland.
  • Buss C; British Heart Foundation Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, EH16 4TJ, UK.
  • Jones MJ; Department of Chronic Diseases and Ageing, Norwegian Institute of Public Health, Oslo, 0213, Norway.
  • Lin DTS; Center for Fertility and Health, Norwegian Institute of Public Health, Oslo, 0213, Norway.
  • MacIsaac JL; Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, U.S. Department of Health and Human Services, Research Triangle Park, North Carolina, 20814, USA.
  • Kobor MS; Ludmer Centre for Neuroinformatics and Mental Health, Douglas Mental Health University Institute, McGill University, Montreal, H3A 2B4, QC, Canada.
  • Koen N; Sackler Program for Epigenetics and Psychobiology at McGill University, Montreal, H3A 0G4, QC, Canada.
  • Zar HJ; Ludmer Centre for Neuroinformatics and Mental Health, Douglas Mental Health University Institute, McGill University, Montreal, H3A 2B4, QC, Canada.
  • Koenen KC; Ludmer Centre for Neuroinformatics and Mental Health, Douglas Mental Health University Institute, McGill University, Montreal, H3A 2B4, QC, Canada.
  • Dalvie S; Sackler Program for Epigenetics and Psychobiology at McGill University, Montreal, H3A 0G4, QC, Canada.
  • Stein DJ; Singapore Institute for Clinical Sciences, Singapore, 117609, Singapore.
  • Kondofersky I; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Institute of Medical Psychology, Berlin, 10117, Germany.
  • Müller NS; University of California, Irvine, Development, Health, and Disease Research Program, Orange, CA, 92697, USA.
  • Theis FJ; University of California, Irvine, Development, Health, and Disease Research Program, Orange, CA, 92697, USA.
  • Räikkönen K; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Institute of Medical Psychology, Berlin, 10117, Germany.
  • Binder EB; University of California, Irvine, Development, Health, and Disease Research Program, Orange, CA, 92697, USA.
Nat Commun ; 10(1): 2548, 2019 06 11.
Article em En | MEDLINE | ID: mdl-31186427
ABSTRACT
Epigenetic processes, including DNA methylation (DNAm), are among the mechanisms allowing integration of genetic and environmental factors to shape cellular function. While many studies have investigated either environmental or genetic contributions to DNAm, few have assessed their integrated effects. Here we examine the relative contributions of prenatal environmental factors and genotype on DNA methylation in neonatal blood at variably methylated regions (VMRs) in 4 independent cohorts (overall n = 2365). We use Akaike's information criterion to test which factors best explain variability of methylation in the cohort-specific VMRs several prenatal environmental factors (E), genotypes in cis (G), or their additive (G + E) or interaction (GxE) effects. Genetic and environmental factors in combination best explain DNAm at the majority of VMRs. The CpGs best explained by either G, G + E or GxE are functionally distinct. The enrichment of genetic variants from GxE models in GWAS for complex disorders supports their importance for disease risk.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: DNA / Metilação de DNA / Interação Gene-Ambiente Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male / Newborn / Pregnancy Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: DNA / Metilação de DNA / Interação Gene-Ambiente Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male / Newborn / Pregnancy Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Alemanha