Therapeutic plasma exchange in hypertriglyceridemic patients
Turk J Med Sci
; 49(3): 872-878, 2019 06 18.
Article
em En
| MEDLINE
| ID: mdl-31203594
ABSTRACT
Background/aim:
High triglyceride (TG) levels are associated with increases in atherosclerotic cardiovascular disease (CVD), hepatic steatosis, and pancreatitis. Acute pancreatitis is a condition with high mortality. Therapeutic plasma exchange (TPE) in the treatment of hypertriglyceridemic pancreatitis (HTGP) is a rapid and effective treatment modality. In this study, the results of TPE were evaluated and the frequency of lipoprotein lipase (LPL) mutation in these patients was determined. Materials andmethods:
TPE was performed in 31 patients with HTGP at the Adult Therapeutic Apheresis Center.Results:
A TG level under 500 mg/dL was achieved by applying apheresis at a median of 2 times (IQR 22, min 1, max 6) in the 31 cases. LPL mutation was detected in 8 (25.8%) of the 31 hypertriglyceridemia cases. When TG levels before and after TPE were evaluated, the mean TG level before TPE was significantly higher (3132 ± 1472 mg/dL) than the mean TG level afterwards (948 ± 465 mg/dL, P < 0.001). This result represented a decrease of 69.7% TG after TPE.Conclusion:
TPE is a safe, fast, and effective treatment modality in experienced centers.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Troca Plasmática
/
Hipertrigliceridemia
Tipo de estudo:
Observational_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Turk J Med Sci
Ano de publicação:
2019
Tipo de documento:
Article