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Pattern of dopamine signaling during aversive events predicts active avoidance learning.
Stelly, Claire E; Haug, Graham C; Fonzi, Kaitlyn M; Garcia, Miriam A; Tritley, Sean C; Magnon, Alexa P; Ramos, Maria Alicia P; Wanat, Matthew J.
Afiliação
  • Stelly CE; Neurosciences Institute and Department of Biology, University of Texas at San Antonio, San Antonio, TX 78249.
  • Haug GC; Neurosciences Institute and Department of Biology, University of Texas at San Antonio, San Antonio, TX 78249.
  • Fonzi KM; Neurosciences Institute and Department of Biology, University of Texas at San Antonio, San Antonio, TX 78249.
  • Garcia MA; Neurosciences Institute and Department of Biology, University of Texas at San Antonio, San Antonio, TX 78249.
  • Tritley SC; Neurosciences Institute and Department of Biology, University of Texas at San Antonio, San Antonio, TX 78249.
  • Magnon AP; Neurosciences Institute and Department of Biology, University of Texas at San Antonio, San Antonio, TX 78249.
  • Ramos MAP; Neurosciences Institute and Department of Biology, University of Texas at San Antonio, San Antonio, TX 78249.
  • Wanat MJ; Neurosciences Institute and Department of Biology, University of Texas at San Antonio, San Antonio, TX 78249 matthew.wanat@utsa.edu.
Proc Natl Acad Sci U S A ; 116(27): 13641-13650, 2019 07 02.
Article em En | MEDLINE | ID: mdl-31209016
ABSTRACT
Learning to avoid aversive outcomes is an adaptive strategy to limit one's future exposure to stressful events. However, there is considerable variance in active avoidance learning across a population. The mesolimbic dopamine system contributes to behaviors elicited by aversive stimuli, although it is unclear if the heterogeneity in active avoidance learning is explained by differences in dopamine transmission. Furthermore, it is not known how dopamine signals evolve throughout active avoidance learning. To address these questions, we performed voltammetry recordings of dopamine release in the ventral medial striatum throughout training on inescapable footshock and signaled active avoidance tasks. This approach revealed differences in the pattern of dopamine signaling during the aversive cue and the safety period that corresponded to subsequent task performance. Dopamine transmission throughout the footshock bout did not predict performance but rather was modulated by the prior stress exposure. Additionally, we demonstrate that dopamine encodes a safety prediction error signal, which illustrates that ventral medial striatal dopamine release conveys a learning signal during both appetitive and aversive conditions.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aprendizagem da Esquiva / Dopamina Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aprendizagem da Esquiva / Dopamina Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2019 Tipo de documento: Article