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PGC-1α acts as an mediator of Sirtuin2 to protect annulus fibrosus from apoptosis induced by oxidative stress through restraining mitophagy.
Xu, Wen-Ning; Yang, Run-Ze; Zheng, Huo-Liang; Yu, Wei; Zheng, Xin-Feng; Li, Bo; Jiang, Sheng-Dan; Jiang, Lei-Sheng.
Afiliação
  • Xu WN; Department of Clinic of Spine Center, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200082, China.
  • Yang RZ; Department of Clinic of Spine Center, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200082, China.
  • Zheng HL; Department of Clinic of Spine Center, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200082, China.
  • Yu W; Department of Orthopaedics, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China.
  • Zheng XF; Department of Clinic of Spine Center, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200082, China.
  • Li B; Department of Clinic of Spine Center, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200082, China.
  • Jiang SD; Department of Clinic of Spine Center, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200082, China. Electronic address: jiangshengdan@xinhuamed.com.cn.
  • Jiang LS; Department of Clinic of Spine Center, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200082, China. Electronic address: jiangleisheng@xinhuamed.com.cn.
Int J Biol Macromol ; 136: 1007-1017, 2019 Sep 01.
Article em En | MEDLINE | ID: mdl-31238070
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Apoptose / Estresse Oxidativo / Sirtuína 2 / Mitofagia / Anel Fibroso / Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo Limite: Animals Idioma: En Revista: Int J Biol Macromol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Apoptose / Estresse Oxidativo / Sirtuína 2 / Mitofagia / Anel Fibroso / Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo Limite: Animals Idioma: En Revista: Int J Biol Macromol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China