Pyroptosis engagement and bladder urothelial cell-derived exosomes recruit mast cells and induce barrier dysfunction of bladder urothelium after uropathogenic <i>E. coli</i> infection.

Wu, Zonglong; Li, Yan; Liu, Qinggang; Liu, Yaxiao; Chen, Lipeng; Zhao, Hongda; Guo, Hongda; Zhu, Kejia; Zhou, Nan; Chai, Toby C; Shi, Benkang

Pyroptosis engagement and bladder urothelial cell-derived exosomes recruit mast cells and induce barrier dysfunction of bladder urothelium after uropathogenic E. coli infection.

Wu, Zonglong; Li, Yan; Liu, Qinggang; Liu, Yaxiao; Chen, Lipeng; Zhao, Hongda; Guo, Hongda; Zhu, Kejia; Zhou, Nan; Chai, Toby C; Shi, Benkang.

Afiliação

Wu Z; Department of Urology, Qilu Hospital of Shandong University, Jinan, People's Republic of China.
Li Y; Department of Urology, Qilu Hospital of Shandong University, Jinan, People's Republic of China.
Liu Q; Department of Urology, Qilu Hospital of Shandong University, Jinan, People's Republic of China.
Liu Y; Department of Urology, Qilu Hospital of Shandong University, Jinan, People's Republic of China.
Chen L; Department of Urology, Qilu Hospital of Shandong University, Jinan, People's Republic of China.
Zhao H; Department of Urology, Qilu Hospital of Shandong University, Jinan, People's Republic of China.
Guo H; Department of Urology, Qilu Hospital of Shandong University, Jinan, People's Republic of China.
Zhu K; Department of Urology, Qilu Hospital of Shandong University, Jinan, People's Republic of China.
Zhou N; Department of Urology, Qilu Hospital of Shandong University, Jinan, People's Republic of China.
Chai TC; Department of Urology, Yale School of Medicine, New Haven, Connecticut.
Shi B; Department of Urology, Qilu Hospital of Shandong University, Jinan, People's Republic of China.

Am J Physiol Cell Physiol ; 317(3): C544-C555, 2019 09 01.

Article em En | MEDLINE | ID: mdl-31241987

Assuntos

Infecções por Escherichia coli/metabolismo; Exossomos/metabolismo; Mastócitos/metabolismo; Piroptose/fisiologia; Infecções Urinárias/metabolismo; Urotélio/metabolismo; Animais; Linhagem Celular; Infecções por Escherichia coli/imunologia; Exossomos/imunologia; Feminino; Humanos; Mastócitos/imunologia; Camundongos; Camundongos Endogâmicos C57BL; Bexiga Urinária/imunologia; Bexiga Urinária/metabolismo; Bexiga Urinária/microbiologia; Infecções Urinárias/imunologia; Escherichia coli Uropatogênica; Urotélio/imunologia; Urotélio/microbiologia

Palavras-chave

barrier dysfunction; exosomes; mast cell; pyroptosis; uropathogenic .

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Urinárias / Urotélio / Infecções por Escherichia coli / Exossomos / Piroptose / Mastócitos Limite: Animals / Female / Humans Idioma: En Revista: Am J Physiol Cell Physiol Assunto da revista: FISIOLOGIA Ano de publicação: 2019 Tipo de documento: Article

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