Interpretation of Whole-Genome Sequencing for Enteric Disease Surveillance and Outbreak Investigation.
Foodborne Pathog Dis
; 16(7): 504-512, 2019 07.
Article
em En
| MEDLINE
| ID: mdl-31246502
ABSTRACT
The routine use of whole-genome sequencing (WGS) as part of enteric disease surveillance is substantially enhancing our ability to detect and investigate outbreaks and to monitor disease trends. At the same time, it is revealing as never before the vast complexity of microbial and human interactions that contribute to outbreak ecology. Since WGS analysis is primarily used to characterize and compare microbial genomes with the goal of addressing epidemiological questions, it must be interpreted in an epidemiological context. In this article, we identify common challenges and pitfalls encountered when interpreting sequence data in an enteric disease surveillance and investigation context, and explain how to address them.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Saúde Pública
/
Epidemiologia Molecular
/
Doenças Transmitidas por Alimentos
/
Sequenciamento Completo do Genoma
Tipo de estudo:
Prognostic_studies
/
Screening_studies
Limite:
Humans
Idioma:
En
Revista:
Foodborne Pathog Dis
Assunto da revista:
CIENCIAS DA NUTRICAO
/
MICROBIOLOGIA
/
PARASITOLOGIA
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Geórgia