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Trolox-induced cardiac differentiation is mediated by the inhibition of Wnt/ß-catenin signaling in human embryonic stem cells.
Choe, Mu Seog; Yeo, Han Cheol; Bae, Chang Min; Han, Ho Jae; Baek, Kyung Min; Kim, Joong Sun; Lim, Kyung Seob; Shin, In-Sik; Chang, Woochul; Yun, Seung Pil; Lee, Ho Jin; Lee, Min Young.
Afiliação
  • Choe MS; Department of Molecular Pharmacology, College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, 80 Daehak-ro, Daegu, 41566, Korea.
  • Yeo HC; Department of Molecular Pharmacology, College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, 80 Daehak-ro, Daegu, 41566, Korea.
  • Bae CM; Department of Molecular Pharmacology, College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, 80 Daehak-ro, Daegu, 41566, Korea.
  • Han HJ; Department of Veterinary Physiology, College of Veterinary Medicine, Seoul National University, 1 Gwanak-ro, Seoul, 08826, Korea.
  • Baek KM; Department of Cardiovascular and Neurologic Disease, College of Oriental Medicine, Daegu Haany University, 136 Sincheondong-ro, Daegu, 42158, Korea.
  • Kim JS; Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, 111 Geonjae-ro, Naju, Jeollanam-do 58245, Korea.
  • Lim KS; Futuristic Animal Resource and Research Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanji-ro, Cheongju, Chungcheongbuk-do 28116, Korea.
  • Shin IS; Department of Veterinary Pharmacology, College of Veterinary Medicine (BK21 Project Team), Chonnam National University, 77 Yongbong-ro, Gwangju, 61186, Korea.
  • Chang W; Department of Biology Education, College of Education, Pusan National University, 2 Busandaehak-ro, Busan, 46241, Korea.
  • Yun SP; Department of Pharmacology, School of Medicine, Gyeongsang National University, 15 Jinjudae-ro 816, Jinju, 52727, Korea.
  • Lee HJ; Department of Pharmacology, School of Medicine, Yale University, 333 Cedar street, New Haven, Connecticut, 06520, USA.
  • Lee MY; Department of Molecular Pharmacology, College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, 80 Daehak-ro, Daegu, 41566, Korea.
Cell Biol Int ; 43(12): 1505-1515, 2019 Dec.
Article em En | MEDLINE | ID: mdl-31293030
ABSTRACT
Cardiac differentiation of human pluripotent stem cells may be induced under chemically defined conditions, wherein the regulation of Wnt/ß-catenin pathway is often desirable. Here, we examined the effect of trolox, a vitamin E analog, on the cardiac differentiation of human embryonic stem cells (hESCs). 6-Hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid (Trolox) significantly enhanced cardiac differentiation in a time- and dose-dependent manner after the mesodermal differentiation of hESCs. Trolox promoted hESC cardiac differentiation through its inhibitory activity against the Wnt/ß-catenin pathway. This study demonstrates an efficient cardiac differentiation method and reveals a novel Wnt/ß-catenin regulator.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Cell Biol Int Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Cell Biol Int Ano de publicação: 2019 Tipo de documento: Article