Characterization of Genetic Variation in CYP3A4 on the Metabolism of Cabozantinib in Vitro.

Lin, Qian-Meng; Li, Ying-Hui; Lu, Xiang-Ran; Wang, Ru; Pang, Ni-Hong; Xu, Ren-Ai; Cai, Jian-Ping; Hu, Guo-Xin

Lin, Qian-Meng; Li, Ying-Hui; Lu, Xiang-Ran; Wang, Ru; Pang, Ni-Hong; Xu, Ren-Ai; Cai, Jian-Ping; Hu, Guo-Xin.

Afiliação

Lin QM; School of Pharmaceutical Sciences , Wenzhou Medical University , 325035 Wenzhou , PR China.
Li YH; School of Pharmaceutical Sciences , Wenzhou Medical University , 325035 Wenzhou , PR China.
Lu XR; School of Pharmaceutical Sciences , Wenzhou Medical University , 325035 Wenzhou , PR China.
Wang R; School of Pharmaceutical Sciences , Wenzhou Medical University , 325035 Wenzhou , PR China.
Pang NH; School of Pharmaceutical Sciences , Wenzhou Medical University , 325035 Wenzhou , PR China.
Xu RA; The First Affiliated Hospital of Wenzhou Medical University , 325035 Wenzhou , PR China.
Cai JP; The Ministry of Health (MOH) Key Laboratory of Geriatrics, Beijing Hospital , National Center of Gerontology , 100000 Beijing , PR China.
Hu GX; School of Pharmaceutical Sciences , Wenzhou Medical University , 325035 Wenzhou , PR China.

Chem Res Toxicol ; 32(8): 1583-1590, 2019 08 19.

Article em En | MEDLINE | ID: mdl-31293154

Assuntos

Anilidas/metabolismo; Citocromo P-450 CYP3A/metabolismo; Inibidores de Proteínas Quinases/metabolismo; Piridinas/metabolismo; Alelos; Citocromo P-450 CYP3A/genética; Variação Genética/genética; Humanos; Cetoconazol/metabolismo; Cinética; Fígado/enzimologia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridinas / Inibidores de Proteínas Quinases / Citocromo P-450 CYP3A / Anilidas Tipo de estudo: Guideline Limite: Humans Idioma: En Revista: Chem Res Toxicol Assunto da revista: TOXICOLOGIA Ano de publicação: 2019 Tipo de documento: Article

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