Inhibition of Anaplerotic Glutaminolysis Underlies Selenite Toxicity in Human Lung Cancer.

Bruntz, Ronald C; Belshoff, Alex C; Zhang, Yan; Macedo, Jessica K A; Higashi, Richard M; Lane, Andrew N; Fan, Teresa W-M

Inhibition of Anaplerotic Glutaminolysis Underlies Selenite Toxicity in Human Lung Cancer.

Bruntz, Ronald C; Belshoff, Alex C; Zhang, Yan; Macedo, Jessica K A; Higashi, Richard M; Lane, Andrew N; Fan, Teresa W-M.

Afiliação

Bruntz RC; Center for Environmental and Systems Biochemistry, Markey Cancer Center, and Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY, 40536-0596, USA.
Belshoff AC; Department of Chemistry, University of Louisville, Louisville, KY, 40292, USA.
Zhang Y; Center for Environmental and Systems Biochemistry, Markey Cancer Center, and Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY, 40536-0596, USA.
Macedo JKA; Center for Environmental and Systems Biochemistry, Markey Cancer Center, and Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY, 40536-0596, USA.
Higashi RM; Center for Environmental and Systems Biochemistry, Markey Cancer Center, and Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY, 40536-0596, USA.
Lane AN; Center for Environmental and Systems Biochemistry, Markey Cancer Center, and Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY, 40536-0596, USA.
Fan TW; Center for Environmental and Systems Biochemistry, Markey Cancer Center, and Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY, 40536-0596, USA.

Proteomics ; 19(21-22): e1800486, 2019 11.

Article em En | MEDLINE | ID: mdl-31298457

Assuntos

Glutaminase/genética; Neoplasias Pulmonares/tratamento farmacológico; Metabolômica; Ácido Selenioso/farmacologia; Células A549; Antineoplásicos/farmacologia; Autofagia/efeitos dos fármacos; Proliferação de Células/efeitos dos fármacos; Ciclo do Ácido Cítrico/efeitos dos fármacos; Feminino; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Glucose/metabolismo; Ácido Glutâmico/genética; Ácido Glutâmico/metabolismo; Humanos; Neoplasias Pulmonares/genética; Neoplasias Pulmonares/patologia; Masculino; Redes e Vias Metabólicas/genética; Estresse Oxidativo/efeitos dos fármacos; Espécies Reativas de Oxigênio/metabolismo

Palavras-chave

[13C5,;15N2]-glutamine; [13C6]-glucose; glutaminolysis; lung cancer; selenite; stable isotope-resolved metabolomics

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácido Selenioso / Metabolômica / Glutaminase / Neoplasias Pulmonares Limite: Female / Humans / Male Idioma: En Revista: Proteomics Assunto da revista: BIOQUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos

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