Discovery of Environment-Sensitive Fluorescent Agonists for &#945;<sub>1</sub>-Adrenergic Receptors.

Qin, Xiaojun; Ma, Zhao; Yang, Xingye; Hu, Shilong; Chen, Xinxin; Liang, Dong; Lin, Yuxing; Shi, Xiaodong; Du, Lupei; Li, Minyong

Discovery of Environment-Sensitive Fluorescent Agonists for α₁-Adrenergic Receptors.

Qin, Xiaojun; Ma, Zhao; Yang, Xingye; Hu, Shilong; Chen, Xinxin; Liang, Dong; Lin, Yuxing; Shi, Xiaodong; Du, Lupei; Li, Minyong.

Afiliação

Qin X; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy , Shandong University , Jinan , Shandong 250012 , China.
Ma Z; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy , Shandong University , Jinan , Shandong 250012 , China.
Yang X; Department of Biochemistry and Molecular Medicine, UC Davis Comprehensive Cancer Center , University of California , Davis, Sacramento , California 95817 , United States.
Hu S; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy , Shandong University , Jinan , Shandong 250012 , China.
Chen X; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy , Shandong University , Jinan , Shandong 250012 , China.
Liang D; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy , Shandong University , Jinan , Shandong 250012 , China.
Lin Y; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy , Shandong University , Jinan , Shandong 250012 , China.
Shi X; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy , Shandong University , Jinan , Shandong 250012 , China.
Du L; Department of Chemistry , University of South Florida , Tampa , Florida 33620 , United States.
Li M; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy , Shandong University , Jinan , Shandong 250012 , China.

Anal Chem ; 91(19): 12173-12180, 2019 10 01.

Article em En | MEDLINE | ID: mdl-31321979

Assuntos

Agonistas de Receptores Adrenérgicos alfa 1/química; Agonistas de Receptores Adrenérgicos alfa 1/farmacologia; Ensaios de Triagem em Larga Escala/métodos; Receptores Adrenérgicos alfa 1/metabolismo; Agonistas de Receptores Adrenérgicos alfa 1/metabolismo; Ligação Competitiva; Cálcio/metabolismo; Fluorescência; Polarização de Fluorescência; Corantes Fluorescentes/química; Células HEK293; Humanos; Luminescência; Imagem Molecular/métodos; Nitrocompostos/química; Oxidiazóis/química; Fenilefrina/química

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores Adrenérgicos alfa 1 / Ensaios de Triagem em Larga Escala / Agonistas de Receptores Adrenérgicos alfa 1 Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: Anal Chem Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China

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