Incidence and outcomes of radiation-induced late cranial neuropathy in 10-year survivors of head and neck cancer.
Oral Oncol
; 95: 59-64, 2019 08.
Article
em En
| MEDLINE
| ID: mdl-31345395
ABSTRACT
OBJECTIVES:
To characterize the late cranial neuropathy among 10-year survivors of head and neck cancer treatment. MATERIALS ANDMETHODS:
We retrospectively evaluated patients treated with curative-intent radiation for HNC between 1990 and 2005 at a single institution with systematic multidisciplinary follow-upâ¯≥â¯10â¯years. New findings of CNP were considered radiation-induced when examination, imaging and/or biopsy did not demonstrate a structural or malignant cause. Cox proportional hazards modeling was used for univariable analysis (UVA) and multivariable analysis (MVA) for time to CNP after completion of radiation.RESULTS:
We identified 112 patients with no evidence of disease and follow-upâ¯≥â¯10â¯years (median 12.2). Sixteen (14%) patients developed at least one CNP. The median time to CNP was 7.7â¯years (range 0.6-10.6â¯years). Most common was CN XII deficit in eight patients (7%), followed by CN X deficit in seven patients (6%). Others included CN V deficit in three, and CN XI deficit in two. Eight of the thirteen patients with a CN X and/or CN XII deficit required a permanent gastrostomy tube. On UVA, site of primary disease, post-radiation neck dissection, chemotherapy, and radiation dose were significantly associated with increased risk of CNP.CONCLUSION:
Iatrogenic CNP may develop years after head and neck cancer treatment and often leads to swallowing dysfunction. Long-term follow up is essential for these patients receiving head and neck radiation.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Lesões por Radiação
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Radioterapia Adjuvante
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Doenças dos Nervos Cranianos
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Sobreviventes de Câncer
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Neoplasias de Cabeça e Pescoço
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
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Adult
/
Aged
/
Aged80
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Female
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Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Oral Oncol
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Estados Unidos