Efficient Click Synthesis of a Protonized and Reduction-Sensitive Amphiphilic Small-Molecule Prodrug Containing Camptothecin and Gemcitabine for a Drug Self-Delivery System.

Dong, Shuxiang; He, Jinlin; Sun, Yue; Li, Dian; Li, Lei; Zhang, Mingzu; Ni, Peihong

Dong, Shuxiang; He, Jinlin; Sun, Yue; Li, Dian; Li, Lei; Zhang, Mingzu; Ni, Peihong.

Afiliação

Dong S; College of Chemistry, Chemical Engineering and Materials Science, State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, Suzhou Key Laboratory of Macromolecular Design and Precision Synthesi
He J; College of Chemistry, Chemical Engineering and Materials Science, State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, Suzhou Key Laboratory of Macromolecular Design and Precision Synthesi
Sun Y; College of Chemistry, Chemical Engineering and Materials Science, State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, Suzhou Key Laboratory of Macromolecular Design and Precision Synthesi
Li D; College of Chemistry, Chemical Engineering and Materials Science, State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, Suzhou Key Laboratory of Macromolecular Design and Precision Synthesi
Li L; College of Chemistry, Chemical Engineering and Materials Science, State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, Suzhou Key Laboratory of Macromolecular Design and Precision Synthesi
Zhang M; College of Chemistry, Chemical Engineering and Materials Science, State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, Suzhou Key Laboratory of Macromolecular Design and Precision Synthesi
Ni P; College of Chemistry, Chemical Engineering and Materials Science, State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, Suzhou Key Laboratory of Macromolecular Design and Precision Synthesi

Mol Pharm ; 16(9): 3770-3779, 2019 09 03.

Article em En | MEDLINE | ID: mdl-31348660

Assuntos

Camptotecina/química; Química Click/métodos; Desoxicitidina/análogos & derivados; Sistemas de Liberação de Medicamentos/métodos; Nanopartículas/química; Pró-Fármacos/química; Animais; Antineoplásicos/química; Antineoplásicos/farmacocinética; Camptotecina/análogos & derivados; Camptotecina/farmacocinética; Sobrevivência Celular/efeitos dos fármacos; Desoxicitidina/química; Desoxicitidina/farmacocinética; Liberação Controlada de Fármacos; Estabilidade de Medicamentos; Meia-Vida; Células Hep G2; Humanos; Concentração de Íons de Hidrogênio; Interações Hidrofóbicas e Hidrofílicas; Masculino; Pró-Fármacos/farmacocinética; Ratos; Ratos Sprague-Dawley; Distribuição Tecidual; Triazóis/química; Triazóis/farmacocinética; Gencitabina

Palavras-chave

cancer therapy; drug self-delivery systems; drug−drug conjugate; nanomedicine; small-molecule prodrug

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Camptotecina / Pró-Fármacos / Sistemas de Liberação de Medicamentos / Desoxicitidina / Nanopartículas / Química Click Tipo de estudo: Diagnostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Mol Pharm Assunto da revista: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Ano de publicação: 2019 Tipo de documento: Article

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