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Genetic Similarity Assessment of Twin-Family Populations by Custom-Designed Genotyping Array.
Beck, Jeffrey J; Hottenga, Jouke-Jan; Mbarek, Hamdi; Finnicum, Casey T; Ehli, Erik A; Hur, Yoon-Mi; Martin, Nicholas G; de Geus, Eco J C; Boomsma, Dorret I; Davies, Gareth E.
Afiliação
  • Beck JJ; Avera Institute for Human Genetics, Avera McKennan Hospital & University Health Center, Sioux Falls, SD, USA.
  • Hottenga JJ; Department of Biological Psychology, Behavioral and Movement Sciences, Vrije Universiteit, Amsterdam, the Netherlands.
  • Mbarek H; Department of Biological Psychology, Behavioral and Movement Sciences, Vrije Universiteit, Amsterdam, the Netherlands.
  • Finnicum CT; Avera Institute for Human Genetics, Avera McKennan Hospital & University Health Center, Sioux Falls, SD, USA.
  • Ehli EA; Avera Institute for Human Genetics, Avera McKennan Hospital & University Health Center, Sioux Falls, SD, USA.
  • Hur YM; Department of Education, Education Research Institute, Mokpo National University, Jeonnam, South Korea.
  • Martin NG; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • de Geus EJC; Department of Biological Psychology, Behavioral and Movement Sciences, Vrije Universiteit, Amsterdam, the Netherlands.
  • Boomsma DI; Avera Institute for Human Genetics, Avera McKennan Hospital & University Health Center, Sioux Falls, SD, USA.
  • Davies GE; Department of Biological Psychology, Behavioral and Movement Sciences, Vrije Universiteit, Amsterdam, the Netherlands.
Twin Res Hum Genet ; 22(4): 210-219, 2019 08.
Article em En | MEDLINE | ID: mdl-31379313
Twin registries often take part in large collaborative projects and are major contributors to genome-wide association (GWA) meta-analysis studies. In this article, we describe genotyping of twin-family populations from Australia, the Midwestern USA (Avera Twin Register), the Netherlands (Netherlands Twin Register), as well as a sample of mothers of twins from Nigeria to assess the extent, if any, of genetic differences between them. Genotyping in all cohorts was done using a custom-designed Illumina Global Screening Array (GSA), optimized to improve imputation quality for population-specific GWA studies. We investigated the degree of genetic similarity between the populations using several measures of population variation with genotype data generated from the GSA. Visualization of principal component analysis (PCA) revealed that the Australian, Dutch and Midwestern American populations exhibit negligible interpopulation stratification when compared to each other, to a reference European population and to globally distant populations. Estimations of fixation indices (FST values) between the Australian, Midwestern American and Netherlands populations suggest minimal genetic differentiation compared to the estimates between each population and a genetically distinct cohort (i.e., samples from Nigeria genotyped on GSA). Thus, results from this study demonstrate that genotype data from the Australian, Dutch and Midwestern American twin-family populations can be reasonably combined for joint-genetic analysis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Gêmeos / Doenças em Gêmeos / Estudo de Associação Genômica Ampla / Técnicas de Genotipagem Tipo de estudo: Systematic_reviews Limite: Humans País/Região como assunto: Africa / America do norte / Europa / Oceania Idioma: En Revista: Twin Res Hum Genet Assunto da revista: GENETICA MEDICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Gêmeos / Doenças em Gêmeos / Estudo de Associação Genômica Ampla / Técnicas de Genotipagem Tipo de estudo: Systematic_reviews Limite: Humans País/Região como assunto: Africa / America do norte / Europa / Oceania Idioma: En Revista: Twin Res Hum Genet Assunto da revista: GENETICA MEDICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos