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A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A.
Doherty, William; Dürr, Eva-Maria; Baddock, Hannah T; Lee, Sook Y; McHugh, Peter J; Brown, Tom; Senge, Mathias O; Scanlan, Eoin M; McGouran, Joanna F.
Afiliação
  • Doherty W; School of Chemistry and Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse St, Dublin 2, Ireland. jmcgoura@tcd.ie.
  • Dürr EM; School of Chemistry and Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse St, Dublin 2, Ireland. jmcgoura@tcd.ie.
  • Baddock HT; Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK.
  • Lee SY; Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK and Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK.
  • McHugh PJ; Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK.
  • Brown T; Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK.
  • Senge MO; Molecular Medicine, Trinity Translational Medicine Institute, Trinity Centre for Health Sciences, Trinity College Dublin, The University of Dublin, St James's Hospital, Dublin 8, Ireland.
  • Scanlan EM; School of Chemistry and Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse St, Dublin 2, Ireland. jmcgoura@tcd.ie.
  • McGouran JF; School of Chemistry and Trinity Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse St, Dublin 2, Ireland. jmcgoura@tcd.ie.
Org Biomol Chem ; 17(35): 8094-8105, 2019 09 21.
Article em En | MEDLINE | ID: mdl-31380542
ABSTRACT
Nine modified nucleosides, incorporating zinc-binding pharmacophores, have been synthesised and evaluated as inhibitors of the DNA repair nuclease SNM1A. The series included oxyamides, hydroxamic acids, hydroxamates, a hydrazide, a squarate ester and a squaramide. A hydroxamic acid-derived nucleoside inhibited the enzyme, offering a novel approach for potential therapeutic development through the use of rationally designed nucleoside derived inhibitors.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Ciclo Celular / Inibidores Enzimáticos / Exodesoxirribonucleases / Ácidos Hidroxâmicos Limite: Humans Idioma: En Revista: Org Biomol Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Irlanda
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Ciclo Celular / Inibidores Enzimáticos / Exodesoxirribonucleases / Ácidos Hidroxâmicos Limite: Humans Idioma: En Revista: Org Biomol Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Irlanda