A Decade Decoded: Spies and Hackers in the History of TAL Effectors Research.
Annu Rev Phytopathol
; 57: 459-481, 2019 08 25.
Article
em En
| MEDLINE
| ID: mdl-31387457
ABSTRACT
Transcription activator-like effectors (TALEs) from the genus Xanthomonas are proteins with the remarkable ability to directly bind the promoters of genes in the plant host to induce their expression, which often helps bacterial colonization. Metaphorically, TALEs act as spies that infiltrate the plant disguised as high-ranking civilians (transcription factors) to trick the plant into activating weak points that allow an invasion. Current knowledge of how TALEs operate allows researchers to predict their activity (counterespionage) and exploit their function, engineering them to do our bidding (a Manchurian agent). This has been possible thanks particularly to the discovery of their DNA binding mechanism, which obeys specific amino acid-DNA correspondences (the TALE code). Here, we review the history of how researchers discovered the way these proteins work and what has changed in the ten years since the discovery of the code. Recommended music for reading this review can be found in the Supplemental Material.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Xanthomonas
/
Efetores Semelhantes a Ativadores de Transcrição
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Annu Rev Phytopathol
Ano de publicação:
2019
Tipo de documento:
Article