Protegrin-1 cytotoxicity towards mammalian cells positively correlates with the magnitude of conformational changes of the unfolded form upon cell interaction.

Soundrarajan, Nagasundarapandian; Park, Suhyun; Le Van Chanh, Quy; Cho, Hye-Sun; Raghunathan, Govindan; Ahn, Byeongyong; Song, Hyuk; Kim, Jin-Hoi; Park, Chankyu

Soundrarajan, Nagasundarapandian; Park, Suhyun; Le Van Chanh, Quy; Cho, Hye-Sun; Raghunathan, Govindan; Ahn, Byeongyong; Song, Hyuk; Kim, Jin-Hoi; Park, Chankyu.

Afiliação

Soundrarajan N; Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Gwangjin-gu, Seoul, South Korea.
Park S; Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Gwangjin-gu, Seoul, South Korea.
Le Van Chanh Q; Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Gwangjin-gu, Seoul, South Korea.
Cho HS; Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Gwangjin-gu, Seoul, South Korea.
Raghunathan G; Department of Chemistry, University of Konstanz, UniversitÓtsstraße 10, 78457, Konstanz, Germany.
Ahn B; Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Gwangjin-gu, Seoul, South Korea.
Song H; Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Gwangjin-gu, Seoul, South Korea.
Kim JH; Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Gwangjin-gu, Seoul, South Korea.
Park C; Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Gwangjin-gu, Seoul, South Korea. chankyu@konkuk.ac.kr.

Sci Rep ; 9(1): 11569, 2019 08 09.

Article em En | MEDLINE | ID: mdl-31399625

Assuntos

Anti-Infecciosos/toxicidade; Peptídeos Catiônicos Antimicrobianos/toxicidade; Sobrevivência Celular/efeitos dos fármacos; Animais; Anti-Infecciosos/química; Peptídeos Catiônicos Antimicrobianos/química; Linhagem Celular; Células HEK293; Humanos; Camundongos; Modelos Moleculares; Células NIH 3T3; Neurônios/efeitos dos fármacos; Conformação Proteica; Proteínas Recombinantes/química; Proteínas Recombinantes/toxicidade; Retina/efeitos dos fármacos

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sobrevivência Celular / Peptídeos Catiônicos Antimicrobianos / Anti-Infecciosos Limite: Animals / Humans Idioma: En Revista: Sci Rep Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Coréia do Sul

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