Mul1 restrains Parkin-mediated mitophagy in mature neurons by maintaining ER-mitochondrial contacts.

Puri, Rajat; Cheng, Xiu-Tang; Lin, Mei-Yao; Huang, Ning; Sheng, Zu-Hang

Puri, Rajat; Cheng, Xiu-Tang; Lin, Mei-Yao; Huang, Ning; Sheng, Zu-Hang.

Afiliação

Puri R; Synaptic Function Section, The Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Room 2B-215, 35 Convent Drive, Bethesda, MD, 20892-3706, USA.
Cheng XT; Synaptic Function Section, The Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Room 2B-215, 35 Convent Drive, Bethesda, MD, 20892-3706, USA.
Lin MY; Synaptic Function Section, The Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Room 2B-215, 35 Convent Drive, Bethesda, MD, 20892-3706, USA.
Huang N; Synaptic Function Section, The Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Room 2B-215, 35 Convent Drive, Bethesda, MD, 20892-3706, USA.
Sheng ZH; Synaptic Function Section, The Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Room 2B-215, 35 Convent Drive, Bethesda, MD, 20892-3706, USA. shengz@ninds.nih.gov.

Nat Commun ; 10(1): 3645, 2019 08 13.

Article em En | MEDLINE | ID: mdl-31409786

Assuntos

Retículo Endoplasmático/metabolismo; Mitocôndrias/metabolismo; Proteínas Mitocondriais/metabolismo; Mitofagia; Neurônios/metabolismo; Ubiquitina-Proteína Ligases/metabolismo; Animais; Cálcio/metabolismo; Retículo Endoplasmático/genética; GTP Fosfo-Hidrolases/genética; GTP Fosfo-Hidrolases/metabolismo; Humanos; Mitocôndrias/genética; Proteínas Mitocondriais/genética; Neurônios/citologia; Ubiquitina-Proteína Ligases/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Mitocondriais / Ubiquitina-Proteína Ligases / Retículo Endoplasmático / Mitofagia / Mitocôndrias / Neurônios Limite: Animals / Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos

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