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Activation of the NLRP3 and AIM2 inflammasomes in a mouse model of Schistosoma mansoni infection.
Chen, T T W; Cheng, P C; Chang, K C; Cao, J P; Feng, J L; Chen, C C; Lam, H Y P; Peng, S Y.
Afiliação
  • Chen TTW; Department of Biochemistry, School of Medicine, Tzu Chi University, Hualien 97004, Taiwan.
  • Cheng PC; National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention; Key Laboratory of Parasite and Vector Biology, MOH, Shanghai 200025, China.
  • Chang KC; Department of Parasitology and Center for International Tropical medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
  • Cao JP; Institute of Laboratory Medicine and Biotechnology, College of Medicine, Tzu Chi University, Hualien 97004, Taiwan.
  • Feng JL; National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention; Key Laboratory of Parasite and Vector Biology, MOH, Shanghai 200025, China.
  • Chen CC; Institute of Laboratory Medicine and Biotechnology, College of Medicine, Tzu Chi University, Hualien 97004, Taiwan.
  • Lam HYP; Department of Laboratory, Chung-Kang Branch, Cheng-Ching General Hospital, Taichung 40764, Taiwan.
  • Peng SY; Institute of Laboratory Medicine and Biotechnology, College of Medicine, Tzu Chi University, Hualien 97004, Taiwan.
J Helminthol ; 94: e72, 2019 Aug 15.
Article em En | MEDLINE | ID: mdl-31412958
Schistosomiasis is an inflammatory disease that occurs when schistosome species eggs are deposited in the liver, resulting in fibrosis and portal hypertension. Schistosomes can interact with host inflammasomes to elicit host immune responses, leading to mitochondrial damage, generation of high levels of reactive oxygen species (ROS) and activation of apoptosis during inflammation. This study aims to examine whether ROS and NF-κB (p65) expression elicited other types of inflammasome activation in Schistosoma mansoni-infected mouse livers. We examine the relationship between inflammasome activation, mitochondrial damage and ROS production in mouse livers infected with S. mansoni. We demonstrate a significant release of ROS and superoxides and increased NF-κB (p65) in S. mansoni-infected mouse livers. Moreover, activation of the NLRP3 and AIM2 inflammasomes was triggered by S. mansoni infection. Stimulation of HuH-7 hepatocellular carcinoma cells with soluble egg antigen induced activation of the AIM2 inflammasome pathway. In this study, we demonstrate that S. mansoni infection promotes both NLRP3 and AIM2 inflammasome activation.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esquistossomose mansoni / Proteínas de Ligação a DNA / Inflamassomos / Proteína 3 que Contém Domínio de Pirina da Família NLR Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Helminthol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Taiwan

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esquistossomose mansoni / Proteínas de Ligação a DNA / Inflamassomos / Proteína 3 que Contém Domínio de Pirina da Família NLR Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Helminthol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Taiwan