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Metal Coordination Is Crucial for Geranylgeranyl Diphosphate Synthase-Bisphosphonate Interactions: A Crystallographic and Computational Analysis.
Lisnyansky, Michal; Yariv, Elon; Segal, Omri; Marom, Milit; Loewenstein, Anat; Ben-Tal, Nir; Giladi, Moshe; Haitin, Yoni.
Afiliação
  • Lisnyansky M; Department of Physiology and Pharmacology, Sackler Faculty of Medicine (M.L., M.M., M.G., Y.H.), Department of Biochemistry and Molecular Biology, George S. Wise Faculty of Life Sciences (E.Y., N.B.-T.), and Sackler Faculty of Medicine (O.S., A.L.), Tel Aviv University, Tel Aviv, Israel; Ophthalmolo
  • Yariv E; Department of Physiology and Pharmacology, Sackler Faculty of Medicine (M.L., M.M., M.G., Y.H.), Department of Biochemistry and Molecular Biology, George S. Wise Faculty of Life Sciences (E.Y., N.B.-T.), and Sackler Faculty of Medicine (O.S., A.L.), Tel Aviv University, Tel Aviv, Israel; Ophthalmolo
  • Segal O; Department of Physiology and Pharmacology, Sackler Faculty of Medicine (M.L., M.M., M.G., Y.H.), Department of Biochemistry and Molecular Biology, George S. Wise Faculty of Life Sciences (E.Y., N.B.-T.), and Sackler Faculty of Medicine (O.S., A.L.), Tel Aviv University, Tel Aviv, Israel; Ophthalmolo
  • Marom M; Department of Physiology and Pharmacology, Sackler Faculty of Medicine (M.L., M.M., M.G., Y.H.), Department of Biochemistry and Molecular Biology, George S. Wise Faculty of Life Sciences (E.Y., N.B.-T.), and Sackler Faculty of Medicine (O.S., A.L.), Tel Aviv University, Tel Aviv, Israel; Ophthalmolo
  • Loewenstein A; Department of Physiology and Pharmacology, Sackler Faculty of Medicine (M.L., M.M., M.G., Y.H.), Department of Biochemistry and Molecular Biology, George S. Wise Faculty of Life Sciences (E.Y., N.B.-T.), and Sackler Faculty of Medicine (O.S., A.L.), Tel Aviv University, Tel Aviv, Israel; Ophthalmolo
  • Ben-Tal N; Department of Physiology and Pharmacology, Sackler Faculty of Medicine (M.L., M.M., M.G., Y.H.), Department of Biochemistry and Molecular Biology, George S. Wise Faculty of Life Sciences (E.Y., N.B.-T.), and Sackler Faculty of Medicine (O.S., A.L.), Tel Aviv University, Tel Aviv, Israel; Ophthalmolo
  • Giladi M; Department of Physiology and Pharmacology, Sackler Faculty of Medicine (M.L., M.M., M.G., Y.H.), Department of Biochemistry and Molecular Biology, George S. Wise Faculty of Life Sciences (E.Y., N.B.-T.), and Sackler Faculty of Medicine (O.S., A.L.), Tel Aviv University, Tel Aviv, Israel; Ophthalmolo
  • Haitin Y; Department of Physiology and Pharmacology, Sackler Faculty of Medicine (M.L., M.M., M.G., Y.H.), Department of Biochemistry and Molecular Biology, George S. Wise Faculty of Life Sciences (E.Y., N.B.-T.), and Sackler Faculty of Medicine (O.S., A.L.), Tel Aviv University, Tel Aviv, Israel; Ophthalmolo
Mol Pharmacol ; 96(5): 580-588, 2019 11.
Article em En | MEDLINE | ID: mdl-31427399
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cristalografia por Raios X / Dimetilaliltranstransferase / Difosfonatos / Farnesiltranstransferase / Geraniltranstransferase / Simulação de Acoplamento Molecular / Magnésio Limite: Humans Idioma: En Revista: Mol Pharmacol Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cristalografia por Raios X / Dimetilaliltranstransferase / Difosfonatos / Farnesiltranstransferase / Geraniltranstransferase / Simulação de Acoplamento Molecular / Magnésio Limite: Humans Idioma: En Revista: Mol Pharmacol Ano de publicação: 2019 Tipo de documento: Article