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Genetic dereplication of Trichoderma hypoxylon reveals two novel polycyclic lactones.
Chen, Lin; Wu, HongBo; Liu, Huan; Li, Erwei; Ren, Jinwei; Wang, Wenzhao; Wang, Shihua; Yin, Wen-Bing.
Afiliação
  • Chen L; State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; Zhengzhou Key Laboratory of Synthetic Biology of Natural Products, Huanghe Science and Technology College, Zhengzhou 450006, China.
  • Wu H; State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
  • Liu H; State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
  • Li E; State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
  • Ren J; State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
  • Wang W; State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
  • Wang S; College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China. Electronic address: wshyyl@sina.com.
  • Yin WB; State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; Savaid Medical School, University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: yinwb@im.ac.cn.
Bioorg Chem ; 91: 103185, 2019 10.
Article em En | MEDLINE | ID: mdl-31430681
ABSTRACT
Previous study demonstrated large scale production of trichochecenes which limited the discovery of novel metabolites in Trichoderma hypoxylon. By genetic deletion of trichothecene synthase encoding gene thtri5, we created the dereplication mutant which eliminated the production of trichothecenes. Through chemical isolation, we characterized a couple of rare new polycyclic lactones tricholactones A and B from the thtri5 deletion strain. The structures of these two compounds were well determined by NMR, HR-ESI-MS and IECD analysis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trichoderma / Deleção de Genes / Carbono-Carbono Liases / Tricotecenos do Tipo A / Tricotecenos do Tipo B / Mutação Idioma: En Revista: Bioorg Chem Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trichoderma / Deleção de Genes / Carbono-Carbono Liases / Tricotecenos do Tipo A / Tricotecenos do Tipo B / Mutação Idioma: En Revista: Bioorg Chem Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China