From skeletal muscle weakness to functional outcomes following critical illness: a translational biology perspective.
Thorax
; 74(11): 1091-1098, 2019 11.
Article
em En
| MEDLINE
| ID: mdl-31431489
ABSTRACT
Intensive care unit acquired weakness (ICUAW) is now a well-known entity complicating critical illness. It increases mortality and in the critical illness survivor it is associated with physical disability, substantially increased health resource utilisation and healthcare costs. Skeletal muscle wasting is a key driver of ICUAW and physical functional outcomes in both the short and long term. To date, there is no intervention that can universally and consistently prevent muscle loss during critical illness, or enhance its recovery following intensive care unit discharge, to improve physical function. Clinical trials of early mobilisation or exercise training, or enhanced nutritional support have generated inconsistent results and we have no effective pharmacological interventions. This review will delineate our current understanding of the mechanisms underpinning the development and persistence of skeletal muscle loss and dysfunction in the critically ill individual, highlighting recent discoveries and clinical observations, and utilisation of this knowledge in the development of novel therapeutics.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Atrofia Muscular
/
Músculo Esquelético
/
Debilidade Muscular
/
Cuidados Críticos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Thorax
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Canadá