Assays with recombinant soluble isoforms of DC-SIGN, a dengue virus ligand, show variation in their ability to bind to mannose residues.
Arch Virol
; 164(11): 2793-2797, 2019 Nov.
Article
em En
| MEDLINE
| ID: mdl-31440811
ABSTRACT
The DC-SIGN glycoprotein is responsible for the initial adhesion of dengue virus (DENV) to immune cells by the carbohydrate recognition domain (CRD). There are thirteen soluble and membrane-bound DC-SIGN isoforms, but the role of soluble isoforms in the DENV internalization process is not known. Five isoforms with an altered or absent CRD were identified, and three different soluble isoforms were used to confirm the interactions with mannose residues. The results show the loss of binding ability of one soluble isoform and binding ability of two of them. All of them will be used to verify their role in the DENV internalization process.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Moléculas de Adesão Celular
/
Receptores de Superfície Celular
/
Vírus da Dengue
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Lectinas Tipo C
/
Ligação Viral
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Internalização do Vírus
/
Manose
Idioma:
En
Revista:
Arch Virol
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Brasil