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Travel Surveillance and Genomics Uncover a Hidden Zika Outbreak during the Waning Epidemic.
Grubaugh, Nathan D; Saraf, Sharada; Gangavarapu, Karthik; Watts, Alexander; Tan, Amanda L; Oidtman, Rachel J; Ladner, Jason T; Oliveira, Glenn; Matteson, Nathaniel L; Kraemer, Moritz U G; Vogels, Chantal B F; Hentoff, Aaron; Bhatia, Deepit; Stanek, Danielle; Scott, Blake; Landis, Vanessa; Stryker, Ian; Cone, Marshall R; Kopp, Edgar W; Cannons, Andrew C; Heberlein-Larson, Lea; White, Stephen; Gillis, Leah D; Ricciardi, Michael J; Kwal, Jaclyn; Lichtenberger, Paola K; Magnani, Diogo M; Watkins, David I; Palacios, Gustavo; Hamer, Davidson H; Gardner, Lauren M; Perkins, T Alex; Baele, Guy; Khan, Kamran; Morrison, Andrea; Isern, Sharon; Michael, Scott F; Andersen, Kristian G.
Afiliação
  • Grubaugh ND; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: nathan.grubaugh@yale.edu.
  • Saraf S; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Gangavarapu K; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Watts A; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON M5B 1T8, Canada.
  • Tan AL; Department of Biological Sciences, Florida Gulf Coast University, Fort Myers, FL 33965, USA; Bureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Tampa, FL 33612, USA.
  • Oidtman RJ; Department of Biological Sciences and Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN 46556, USA.
  • Ladner JT; Center for Genome Sciences, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA; Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ 86011, USA.
  • Oliveira G; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Matteson NL; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Kraemer MUG; Department of Zoology, University of Oxford, Oxford OX1 3PS, UK; Boston Children's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA.
  • Vogels CBF; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA.
  • Hentoff A; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, USA.
  • Bhatia D; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON M5B 1T8, Canada.
  • Stanek D; Bureau of Epidemiology, Division of Disease Control and Health Protection, Florida Department of Health, Tallahassee, FL 32399, USA.
  • Scott B; Bureau of Epidemiology, Division of Disease Control and Health Protection, Florida Department of Health, Tallahassee, FL 32399, USA.
  • Landis V; Bureau of Epidemiology, Division of Disease Control and Health Protection, Florida Department of Health, Tallahassee, FL 32399, USA.
  • Stryker I; Bureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Tampa, FL 33612, USA.
  • Cone MR; Bureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Tampa, FL 33612, USA.
  • Kopp EW; Bureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Tampa, FL 33612, USA.
  • Cannons AC; Bureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Tampa, FL 33612, USA.
  • Heberlein-Larson L; Bureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Tampa, FL 33612, USA.
  • White S; Bureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Miami, FL 33125, USA.
  • Gillis LD; Bureau of Public Health Laboratories, Division of Disease Control and Health Protection, Florida Department of Health, Miami, FL 33125, USA.
  • Ricciardi MJ; Department of Pathology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
  • Kwal J; Department of Pathology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
  • Lichtenberger PK; Department of Pathology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
  • Magnani DM; Department of Pathology, University of Miami Miller School of Medicine, Miami, FL 33136, USA; MassBiologics, University of Massachusetts Medical School, Boston, MA 02126, USA.
  • Watkins DI; Department of Pathology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
  • Palacios G; Center for Genome Sciences, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA.
  • Hamer DH; Department of Global Health, Boston University School of Public Health, Boston, MA 02118, USA; Section of Infectious Diseases, Department of Medicine, Boston Medical Center, Boston, MA 02118, USA.
  • Gardner LM; School of Civil and Environmental Engineering, UNSW Sydney, Sydney, NSW 2052, Australia; Department of Civil Engineering, Johns Hopkins University, Baltimore, MD 21287, USA.
  • Perkins TA; Department of Biological Sciences and Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN 46556, USA.
  • Baele G; Department of Microbiology and Immunology, Rega Institute, KU Leuven, Leuven, Belgium.
  • Khan K; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON M5B 1T8, Canada; Division of Infectious Diseases, Department of Medicine, University of Toronto, Toronto, ON M5B 1T8, Canada.
  • Morrison A; Bureau of Epidemiology, Division of Disease Control and Health Protection, Florida Department of Health, Tallahassee, FL 32399, USA.
  • Isern S; Department of Biological Sciences, Florida Gulf Coast University, Fort Myers, FL 33965, USA.
  • Michael SF; Department of Biological Sciences, Florida Gulf Coast University, Fort Myers, FL 33965, USA. Electronic address: smichael@fgcu.edu.
  • Andersen KG; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA; Scripps Research Translational Institute, La Jolla, CA 92037, USA. Electronic address: andersen@scripps.edu.
Cell ; 178(5): 1057-1071.e11, 2019 08 22.
Article em En | MEDLINE | ID: mdl-31442400
ABSTRACT
The Zika epidemic in the Americas has challenged surveillance and control. As the epidemic appears to be waning, it is unclear whether transmission is still ongoing, which is exacerbated by discrepancies in reporting. To uncover locations with lingering outbreaks, we investigated travel-associated Zika cases to identify transmission not captured by reporting. We uncovered an unreported outbreak in Cuba during 2017, a year after peak transmission in neighboring islands. By sequencing Zika virus, we show that the establishment of the virus was delayed by a year and that the ensuing outbreak was sparked by long-lived lineages of Zika virus from other Caribbean islands. Our data suggest that, although mosquito control in Cuba may initially have been effective at mitigating Zika virus transmission, such measures need to be maintained to be effective. Our study highlights how Zika virus may still be "silently" spreading and provides a framework for understanding outbreak dynamics. VIDEO ABSTRACT.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Genômica / Epidemias / Infecção por Zika virus Tipo de estudo: Incidence_studies / Prognostic_studies / Screening_studies Limite: Animals / Humans País/Região como assunto: Caribe / Cuba Idioma: En Revista: Cell Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Genômica / Epidemias / Infecção por Zika virus Tipo de estudo: Incidence_studies / Prognostic_studies / Screening_studies Limite: Animals / Humans País/Região como assunto: Caribe / Cuba Idioma: En Revista: Cell Ano de publicação: 2019 Tipo de documento: Article