Structure of Membrane-Bound Huntingtin Exon 1 Reveals Membrane Interaction and Aggregation Mechanisms.

Tao, Meixin; Pandey, Nitin K; Barnes, Ryan; Han, Songi; Langen, Ralf

Tao, Meixin; Pandey, Nitin K; Barnes, Ryan; Han, Songi; Langen, Ralf.

Afiliação

Tao M; Department of Neuroscience and Physiology, Department of Biochemistry and Molecular Medicine, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Pandey NK; Department of Neuroscience and Physiology, Department of Biochemistry and Molecular Medicine, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Barnes R; Department of Chemistry and Biochemistry, Department of Chemical Engineering, University of California Santa Barbara, Santa Barbara, CA 93106, USA.
Han S; Department of Chemistry and Biochemistry, Department of Chemical Engineering, University of California Santa Barbara, Santa Barbara, CA 93106, USA.
Langen R; Department of Neuroscience and Physiology, Department of Biochemistry and Molecular Medicine, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. Electronic address: langen@usc.edu.

Structure ; 27(10): 1570-1580.e4, 2019 10 01.

Article em En | MEDLINE | ID: mdl-31466833

Assuntos

Membrana Celular/metabolismo; Proteína Huntingtina/química; Proteína Huntingtina/metabolismo; Mutação; Sítios de Ligação; Espectroscopia de Ressonância de Spin Eletrônica; Éxons; Humanos; Proteína Huntingtina/genética; Modelos Moleculares; Peptídeos/genética; Agregados Proteicos; Ligação Proteica; Estrutura Secundária de Proteína

Palavras-chave

EPR; Huntington's disease; ODNP; huntingtin exon 1; membrane-mediated aggregation; polyglutamine expansion; protein misfolding; protein-membrane interaction

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Membrana Celular / Proteína Huntingtina / Mutação Limite: Humans Idioma: En Revista: Structure Assunto da revista: BIOLOGIA MOLECULAR / BIOQUIMICA / BIOTECNOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos

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