Increased platelet function during frailty.
Exp Hematol
; 77: 12-25.e2, 2019 09.
Article
em En
| MEDLINE
| ID: mdl-31476327
ABSTRACT
Frailty is highly associated with cardiovascular diseases (CVD) and diabetes mellitus (DM). Aging, CVD, and DM are all associated with an increase in platelet function. Therefore, the aim of this study was to evaluate platelet function during frailty. We selected a total of 37 older adults who were divided into two groups, frail (nâ¯=â¯16) and robust (nâ¯=â¯21), with a mean age of 72.4 ± 4.4 years (range 65-84 years) in robust adults and 72.6 ± 6.6 years (range 65-88 years) in frail adults; 20 young healthy volunteers, with a mean age of 22.9 ± 2.7 years (range 20-30 years), were included as a control platelet function was determined using the lumi-aggregometer (aggregation) and flow cytometry (platelet activation). We also performed Western blot to evaluate the intraplatelet activation pathways involved in activation. Platelet count decreased and mean platelet volume, aggregation, and P-selectin expression increased during aging compared with young adults was found. We observed an increase in P-selectin expression in frail adults compared with robust adults. We also evaluated the characteristics of the study population to explain this difference and found a higher prevalence of DM and a tendency toward hyperglycemia in frail adults compared with robust adults. In agreement with this, high doses of glucose were able to increase platelet aggregation and P-selectin expression through thrombin receptors and p38 phosphorylation.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plaquetas
/
Envelhecimento
/
Doenças Cardiovasculares
/
Agregação Plaquetária
/
Selectina-P
/
Diabetes Mellitus
/
Fragilidade
Tipo de estudo:
Risk_factors_studies
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Exp Hematol
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Chile