Matrix-degrading protease ADAMTS-5 cleaves inter-&#945;-inhibitor and releases active heavy chain 2 in synovial fluids from arthritic patients.

Scavenius, Carsten; Poulsen, Emil Christian; Thøgersen, Ida B; Roebuck, Margaret; Frostick, Simon; Bou-Gharios, George; Yamamoto, Kazuhiro; Deleuran, Bent; Enghild, Jan J

Matrix-degrading protease ADAMTS-5 cleaves inter-α-inhibitor and releases active heavy chain 2 in synovial fluids from arthritic patients.

Scavenius, Carsten; Poulsen, Emil Christian; Thøgersen, Ida B; Roebuck, Margaret; Frostick, Simon; Bou-Gharios, George; Yamamoto, Kazuhiro; Deleuran, Bent; Enghild, Jan J.

Afiliação

Scavenius C; Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus, Denmark.
Poulsen EC; Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus, Denmark.
Thøgersen IB; Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus, Denmark.
Roebuck M; Department of Molecular and Clinical Medicine, University of Liverpool, Liverpool L69 3BX, United Kingdom.
Frostick S; Department of Molecular and Clinical Medicine, University of Liverpool, Liverpool L69 3BX, United Kingdom.
Bou-Gharios G; Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool L7 8TX, United Kingdom.
Yamamoto K; Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool L7 8TX, United Kingdom.
Deleuran B; Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark.
Enghild JJ; Department of Rheumatology, Aarhus University Hospital, 8200 Aarhus, Denmark.

J Biol Chem ; 294(42): 15495-15504, 2019 10 18.

Article em En | MEDLINE | ID: mdl-31484722

Assuntos

Proteína ADAMTS5/metabolismo; alfa-Globulinas/metabolismo; Artrite/enzimologia; Líquido Sinovial/enzimologia; Proteína ADAMTS5/genética; alfa-Globulinas/química; alfa-Globulinas/genética; Motivos de Aminoácidos; Artrite/genética; Artrite/metabolismo; Matriz Extracelular/enzimologia; Matriz Extracelular/genética; Matriz Extracelular/metabolismo; Humanos; Ácido Hialurônico/metabolismo; Metaloproteinase 13 da Matriz/genética; Metaloproteinase 13 da Matriz/metabolismo; Metaloproteinase 3 da Matriz/genética; Metaloproteinase 3 da Matriz/metabolismo; Metaloproteinase 7 da Matriz/genética; Metaloproteinase 7 da Matriz/metabolismo; Líquido Sinovial/metabolismo

Palavras-chave

ADAMTS; arthritis; bikunin; extracellular matrix protein; hyaluronan; inter-α-inhibitor; metalloprotease

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite / Líquido Sinovial / Alfa-Globulinas / Proteína ADAMTS5 Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Dinamarca

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