Your browser doesn't support javascript.
loading
USP21 deubiquitinase promotes pancreas cancer cell stemness via Wnt pathway activation.
Hou, Pingping; Ma, Xingdi; Zhang, Qiang; Wu, Chang-Jiun; Liao, Wenting; Li, Jun; Wang, Huamin; Zhao, Jun; Zhou, Xin; Guan, Carolyn; Ackroyd, Jeffery; Jiang, Shan; Zhang, Jianhua; Spring, Denise J; Wang, Y Alan; DePinho, Ronald A.
Afiliação
  • Hou P; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
  • Ma X; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
  • Zhang Q; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
  • Wu CJ; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
  • Liao W; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
  • Li J; Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
  • Wang H; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
  • Zhao J; Department of Anatomical Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
  • Zhou X; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
  • Guan C; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
  • Ackroyd J; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
  • Jiang S; Princeton University, Princeton, New Jersey 08544, USA.
  • Zhang J; Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
  • Spring DJ; Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
  • Wang YA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
  • DePinho RA; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77054, USA.
Genes Dev ; 33(19-20): 1361-1366, 2019 10 01.
Article em En | MEDLINE | ID: mdl-31488580
ABSTRACT
The ubiquitin-specific protease (USP) family is the largest group of cysteine proteases. Cancer genomic analysis identified frequent amplification of USP21 (22%) in human pancreatic ductal adenocarcinoma (PDAC). USP21 overexpression correlates with human PDAC progression, and enforced expression of USP21 accelerates murine PDAC tumor growth and drives PanIN to PDAC progression in immortalized human pancreatic ductal cells. Conversely, depletion of USP21 impairs PDAC tumor growth. Mechanistically, USP21 deubiquitinates and stabilizes the TCF/LEF transcription factor TCF7, which promotes cancer cell stemness. Our work identifies and validates USP21 as a PDAC oncogene, providing a potential druggable target for this intractable disease.
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Regulação Neoplásica da Expressão Gênica / Ubiquitina Tiolesterase / Via de Sinalização Wnt Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Genes Dev Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Regulação Neoplásica da Expressão Gênica / Ubiquitina Tiolesterase / Via de Sinalização Wnt Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Genes Dev Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos