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Ex vivo screen identifies CDK12 as a metastatic vulnerability in osteosarcoma.
Bayles, Ian; Krajewska, Malgorzata; Pontius, W Dean; Saiakhova, Alina; Morrow, James J; Bartels, Cynthia; Lu, Jim; Faber, Zachary J; Fedorov, Yuriy; Hong, Ellen S; Karnuta, Jaret M; Rubin, Brian; Adams, Drew J; George, Rani E; Scacheri, Peter C.
Afiliação
  • Bayles I; Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Case Comprehensive Cancer Center, Cleveland, Ohio, USA.
  • Krajewska M; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.
  • Pontius WD; Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Case Comprehensive Cancer Center, Cleveland, Ohio, USA.
  • Saiakhova A; Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Case Comprehensive Cancer Center, Cleveland, Ohio, USA.
  • Morrow JJ; Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Case Comprehensive Cancer Center, Cleveland, Ohio, USA.
  • Bartels C; Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Case Comprehensive Cancer Center, Cleveland, Ohio, USA.
  • Lu J; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.
  • Faber ZJ; Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Case Comprehensive Cancer Center, Cleveland, Ohio, USA.
  • Fedorov Y; Small Molecules Drug Development Core Facility, Office of Research Administration, Case Western Reserve University, Cleveland, Ohio, USA.
  • Hong ES; Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Case Comprehensive Cancer Center, Cleveland, Ohio, USA.
  • Karnuta JM; Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Case Comprehensive Cancer Center, Cleveland, Ohio, USA.
  • Rubin B; Cleveland Clinic Lerner College of Medicine, Cleveland, Ohio, USA.
  • Adams DJ; Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  • George RE; Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Case Comprehensive Cancer Center, Cleveland, Ohio, USA.
  • Scacheri PC; Small Molecules Drug Development Core Facility, Office of Research Administration, Case Western Reserve University, Cleveland, Ohio, USA.
J Clin Invest ; 129(10): 4377-4392, 2019 10 01.
Article em En | MEDLINE | ID: mdl-31498151
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteossarcoma / Quinases Ciclina-Dependentes Limite: Animals / Female / Humans Idioma: En Revista: J Clin Invest Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteossarcoma / Quinases Ciclina-Dependentes Limite: Animals / Female / Humans Idioma: En Revista: J Clin Invest Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos