MAIT cells in metabolic diseases.
Mol Metab
; 27S: S114-S121, 2019 09.
Article
em En
| MEDLINE
| ID: mdl-31500822
ABSTRACT
BACKGROUND:
Metabolic diseases represent a wide category of alterations affecting metabolism. These pathologies are notably marked by inflammation that implicates the immune system. Mucosal Associated Invariant (MAI)T cells are immune cells expressing a semi-invariant TCR able to recognize bacterial and fungal vitamin B metabolites. MAIT cells can promote inflammation and are present in many organs central to metabolism, suggesting a role in the etiopathology of these diseases. SCOPE OF THE REVIEW Here, we will review what is known of the involvement of MAIT cells in metabolic pathologies in humans and mice. MAJORCONCLUSIONS:
MAIT cells are severely affected, overactivated with a frequency reduction and a phenotype shift from protective to deleterious. Therefore, they might be a novel target to treat, in particular, pancreas and liver metabolic diseases.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células T Invariantes Associadas à Mucosa
/
Doenças Metabólicas
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Mol Metab
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
França