The IL-13-OVOL1-FLG axis in atopic dermatitis.
Immunology
; 158(4): 281-286, 2019 12.
Article
em En
| MEDLINE
| ID: mdl-31509236
ABSTRACT
Despite sharing interleukin-4 receptor α (IL-4Rα) in their signaling cascades, IL-4 and IL-13 have different functions in atopic inflammation. IL-13 preferentially participates in the peripheral tissues because tissue-resident group 2 innate lymphoid cells produce IL-13 but not IL-4. In contrast, lymph node T follicular helper cells express IL-4 but not IL-13 to regulate B-cell immunity. The dominant microenvironment of IL-13 is evident in the lesional skin of atopic dermatitis (AD). The IL-13-rich local milieu causes barrier dysfunction by down-regulating the OVOL1-filaggrin (FLG) axis and up-regulating the periostin-IL-24 axis. Genome-wide association studies also point to the crucial involvement of the IL-13, OVOL1 and FLG genes in the pathogenesis of AD. Biologics targeting IL-13, such as the anti-IL-4Rα antibody dupilumab and the anti-IL-13 antibody tralokinumab, successfully improve AD lesions and further highlight the importance of IL-13 in the pathogenesis of AD.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pele
/
Fatores de Transcrição
/
Linfócitos
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Interleucina-13
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Dermatite Atópica
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Proteínas de Ligação a DNA
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Subunidade alfa de Receptor de Interleucina-4
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Proteínas de Filamentos Intermediários
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Immunology
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Japão