Your browser doesn't support javascript.
loading
Comparison of phenotypic and genotypic diagnosis of acute human bocavirus 1 infection in children.
Kols, Nicola Isabelle; Aatola, Heli; Peltola, Ville; Xu, Man; Nora-Krukle, Zaiga; Hedman, Klaus; Zvirbliene, Aurelija; Toivola, Hanna; Vuorinen, Tytti; Koskinen, Juha M; Bruning, Andrea H L; Christensen, Andreas; Söderlund-Venermo, Maria; Koskinen, Janne O.
Afiliação
  • Kols NI; Department of Medical Microbiology, Clinic of Laboratory Medicine, St. Olavs Hospital HF, Trondheim University Hospital, 7006, Trondheim, Norway; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, 7491, Trondheim, N
  • Aatola H; ArcDia International Oy Ltd, 20521, Turku, Finland.
  • Peltola V; Department of Paediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, 20521, Turku, Finland.
  • Xu M; Department of Virology, University of Helsinki, and Helsinki University Hospital, 00290, Helsinki, Finland.
  • Nora-Krukle Z; Department of Virology, University of Helsinki, and Helsinki University Hospital, 00290, Helsinki, Finland; Institute of Microbiology and Virology, Riga Stradins University, LV-1067, Riga, Latvia.
  • Hedman K; Department of Virology, University of Helsinki, and Helsinki University Hospital, 00290, Helsinki, Finland; Helsinki University Hospital, 00029, Helsinki, Finland.
  • Zvirbliene A; Department of Immunology and Cell Biology, Institute of Biotechnology, Life Sciences Center, Vilnius University, LT-10223, Vilnius, Lithuania.
  • Toivola H; ArcDia International Oy Ltd, 20521, Turku, Finland.
  • Vuorinen T; Department of Clinical Microbiology, Turku University Hospital and Department of Virology, University of Turku, 20521, Turku, Finland.
  • Koskinen JM; ArcDia International Oy Ltd, 20521, Turku, Finland.
  • Bruning AHL; Department of Pediatric Infectious Diseases, Emma Children's Hospital, Academic Medical Center, 1105, Amsterdam, the Netherlands.
  • Christensen A; Department of Medical Microbiology, Clinic of Laboratory Medicine, St. Olavs Hospital HF, Trondheim University Hospital, 7006, Trondheim, Norway; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, 7491, Trondheim, N
  • Söderlund-Venermo M; Department of Virology, University of Helsinki, and Helsinki University Hospital, 00290, Helsinki, Finland.
  • Koskinen JO; ArcDia International Oy Ltd, 20521, Turku, Finland.
J Clin Virol ; 120: 17-19, 2019 11.
Article em En | MEDLINE | ID: mdl-31521013
ABSTRACT

BACKGROUND:

Diagnosis of human bocavirus 1 (HBoV1) has been based on qualitative PCRs detecting HBoV1 DNA or detection of HBoV1 mRNA.

OBJECTIVE:

This study aims to assess whether a rapid and automated HBoV1 antigen test is suitable for diagnosis of acute HBoV1 infection. STUDY

DESIGN:

HBoV1 antigen detection has been compared with quantitative HBoV1 DNA PCR and HBoV1 mRNA RT-PCR. RESULTS AND

CONCLUSION:

We conclude that HBoV1 antigen detection has higher clinical specificity and positive predictive value than HBoV1 DNA qualitative PCRs, yet a lower sensitivity than HBoV1 mRNA detection. Additionally, HBoV1 antigen detection is beneficial in its rapidity and availability as a point-of-care test.
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Respiratórias / RNA Mensageiro / Infecções por Parvoviridae / Bocavirus Humano / Antígenos Virais Tipo de estudo: Diagnostic_studies / Prognostic_studies / Qualitative_research Limite: Child / Female / Humans / Male Idioma: En Revista: J Clin Virol Assunto da revista: VIROLOGIA Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Respiratórias / RNA Mensageiro / Infecções por Parvoviridae / Bocavirus Humano / Antígenos Virais Tipo de estudo: Diagnostic_studies / Prognostic_studies / Qualitative_research Limite: Child / Female / Humans / Male Idioma: En Revista: J Clin Virol Assunto da revista: VIROLOGIA Ano de publicação: 2019 Tipo de documento: Article